Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling

Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling

Lithium is widely used as a treatment for Bipolar Disorder although the molecular mechanisms that underlie its therapeutic effects are under debate. In this study, we show brain-derived neurotrophic factor (BDNF) is required for the antimanic-like effects of lithium but not the antidepressant-like e...

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Bibliographic Details
Main Authors: Erinn S Gideons, Pei-Yi Lin, Melissa Mahgoub, Ege T Kavalali, Lisa M Monteggia
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-06-01
Series:eLife
Subjects:
lithium
bdnf
dynamin
endocytosis
mania
Online Access:https://elifesciences.org/articles/25480

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