Ultrasound-assisted multicomponent synthesis of heterocycles in water – A review
Ultrasound-assisted multicomponent reactions in water are great implements for the development of bioactive compounds. The methodologies for the synthesis of different heterocyclic molecules have acquired enormous attention. Many such techniques are energy-intensive and associated with hazardous che...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535221005591 |
| _version_ | 1819319611972124672 |
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| author | Ramakanth Pagadala Venkatesan Kasi Nhlanhla Gracious Shabalala Sreekantha B. Jonnalagadda |
| author_facet | Ramakanth Pagadala Venkatesan Kasi Nhlanhla Gracious Shabalala Sreekantha B. Jonnalagadda |
| author_sort | Ramakanth Pagadala |
| collection | DOAJ |
| description | Ultrasound-assisted multicomponent reactions in water are great implements for the development of bioactive compounds. The methodologies for the synthesis of different heterocyclic molecules have acquired enormous attention. Many such techniques are energy-intensive and associated with hazardous chemicals, solvents, expensive work-ups. Low yields and multi-step schemes generate huge organic waste. Hence, researchers thus focussed on benign and eco-friendly techniques to assemble heterocyclic analogs and drug molecules. The ultrasound-assisted synthesis of the target organic moieties frequently facilitates higher product yields than other methodologies. This review is focused on ultrasound-aided multicomponent reactions for synthesizing varied nitrogen-, oxygen-, and sulfur-containing heterocyclic compounds using water as the solvent. The advantages and limitations with respect to yields and reaction conditions are discussed. This evaluation covered the literature reports from 2014 to date. |
| first_indexed | 2024-12-24T11:06:27Z |
| format | Article |
| id | doaj.art-f2a9364c906c4d3db6c0edd126dfc7a3 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-24T11:06:27Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-f2a9364c906c4d3db6c0edd126dfc7a32022-12-21T16:58:37ZengElsevierArabian Journal of Chemistry1878-53522022-01-01151103544Ultrasound-assisted multicomponent synthesis of heterocycles in water – A reviewRamakanth Pagadala0Venkatesan Kasi1Nhlanhla Gracious Shabalala2Sreekantha B. Jonnalagadda3Chemistry Division, H&S Department, CVR College of Engineering, Hyderabad, India; School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South AfricaChemistry Division, H&S Department, CVR College of Engineering, Hyderabad, IndiaSchool of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South AfricaSchool of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South Africa; Corresponding author.Ultrasound-assisted multicomponent reactions in water are great implements for the development of bioactive compounds. The methodologies for the synthesis of different heterocyclic molecules have acquired enormous attention. Many such techniques are energy-intensive and associated with hazardous chemicals, solvents, expensive work-ups. Low yields and multi-step schemes generate huge organic waste. Hence, researchers thus focussed on benign and eco-friendly techniques to assemble heterocyclic analogs and drug molecules. The ultrasound-assisted synthesis of the target organic moieties frequently facilitates higher product yields than other methodologies. This review is focused on ultrasound-aided multicomponent reactions for synthesizing varied nitrogen-, oxygen-, and sulfur-containing heterocyclic compounds using water as the solvent. The advantages and limitations with respect to yields and reaction conditions are discussed. This evaluation covered the literature reports from 2014 to date.http://www.sciencedirect.com/science/article/pii/S1878535221005591Water as a solventUltrasonic irradiationOne-PotMulticomponent reactionN-, O-, and S-Heterocycles |
| spellingShingle | Ramakanth Pagadala Venkatesan Kasi Nhlanhla Gracious Shabalala Sreekantha B. Jonnalagadda Ultrasound-assisted multicomponent synthesis of heterocycles in water – A review Arabian Journal of Chemistry Water as a solvent Ultrasonic irradiation One-Pot Multicomponent reaction N-, O-, and S-Heterocycles |
| title | Ultrasound-assisted multicomponent synthesis of heterocycles in water – A review |
| title_full | Ultrasound-assisted multicomponent synthesis of heterocycles in water – A review |
| title_fullStr | Ultrasound-assisted multicomponent synthesis of heterocycles in water – A review |
| title_full_unstemmed | Ultrasound-assisted multicomponent synthesis of heterocycles in water – A review |
| title_short | Ultrasound-assisted multicomponent synthesis of heterocycles in water – A review |
| title_sort | ultrasound assisted multicomponent synthesis of heterocycles in water a review |
| topic | Water as a solvent Ultrasonic irradiation One-Pot Multicomponent reaction N-, O-, and S-Heterocycles |
| url | http://www.sciencedirect.com/science/article/pii/S1878535221005591 |
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