COVID-19 breakthrough infection among vaccinated individuals: A cross-sectional study
Background: A cross-sectional study was carried out in urban area. The primary outcome of the study was the proportion of breakthrough infection in vaccinated subjects, which was defined as any COVID-19 infection occurring ≥30 days after receiving both the doses of either of the vaccine(s). Aims...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-07-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/44473 |
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| author | Sushant S Chavan Madhuri Suryawanshi Vikrant Pagar Sarika P Patil Amol D Kinge |
| author_facet | Sushant S Chavan Madhuri Suryawanshi Vikrant Pagar Sarika P Patil Amol D Kinge |
| author_sort | Sushant S Chavan |
| collection | DOAJ |
| description | Background: A cross-sectional study was carried out in urban area. The primary outcome of the study was the proportion of breakthrough infection in vaccinated subjects, which was defined as any COVID-19 infection occurring ≥30 days after receiving both the doses of either of the vaccine(s).
Aims and Objectives: The aims of this study were to determine prevalence of COVID-19 breakthrough infection among COVID 19 vaccinated patients, (1) to study demographic factors affecting breakthrough infection and (2) to compare the proportion of breakthrough infection among Covishield and Covaxin recipients.
Materials and Methods: The subjects were selected by systematic random sample method from available vaccination record. A questionnaire was administered in local language containing demographic information and COVID-related information. Nasopharyngeal swab was taken by trained Interns with all necessary precautions, RT-PCR swab was labeled and sent to PCR laboratory in cold chain for testing.
Results: A total 445 subjects were tested for COVID-19. Subjects included 290 (65.2%) males and 155 (34.8%) females. Maximum cases were from age group of 21–30 year (23.4%). The mean age was found to be 43 year. About 8.85% subjects test result came positive despite taking two doses of either COVID vaccine. Breakthrough infection was more among males than females. Covaxin recipient subjects showed marginally higher percentage of breakthrough infection (9.1%) than Covishield. Out of the 39 breakthrough infections, 16 subjects were having comorbidities. Maximum breakthrough infection was seen in subjects having diabetes mellitus and hypertension both and hypertension alone (1.6%).
Conclusion: A prevalence of 8.8% of COVID-19 breakthrough infection was reported in our study among fully vaccinated subjects after 30 days of last vaccine dose. Males are at higher risk of getting infection. People with comorbidities are at higher risk of breakthrough infection and hospitalization. |
| first_indexed | 2024-12-12T07:17:47Z |
| format | Article |
| id | doaj.art-f2aa2970a36844b185293d20efdd066a |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-12T07:17:47Z |
| publishDate | 2022-07-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-f2aa2970a36844b185293d20efdd066a2022-12-22T00:33:29ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-07-01137813https://doi.org/10.3126/ajms.v13i7.44473COVID-19 breakthrough infection among vaccinated individuals: A cross-sectional studySushant S Chavan 0https://orcid.org/0000-0001-5883-433XMadhuri Suryawanshi 1https://orcid.org/0000-0001-9012-4346Vikrant Pagar 2https://orcid.org/0000-0001-5870-7613Sarika P Patil 3https://orcid.org/0000-0001-8466-897XAmol D Kinge 4https://orcid.org/0000-0003-3615-838XAssistant Professor, Department of Community Medicine, Shri Bhausaheb Hire Government Medical College, Dhule, Maharashtra, India Assistant Professor, Department of Microbiology, Shri Bhausaheb Hire Government Medical College, Dhule, Maharashtra, India Assistant Professor, Department of Community Medicine, Shri Bhausaheb Hire Government Medical College, Dhule, 4Assistant Professor, Department of Community Medicine, Government Medical College, Nandurbar, Maharashtra, India Associate Professor, Department of Community Medicine, Shri Bhausaheb Hire Government Medical College, Dhule, Maharashtra, India Assistant Professor, Department of Community Medicine, Government Medical College, Nandurbar, Maharashtra, India Background: A cross-sectional study was carried out in urban area. The primary outcome of the study was the proportion of breakthrough infection in vaccinated subjects, which was defined as any COVID-19 infection occurring ≥30 days after receiving both the doses of either of the vaccine(s). Aims and Objectives: The aims of this study were to determine prevalence of COVID-19 breakthrough infection among COVID 19 vaccinated patients, (1) to study demographic factors affecting breakthrough infection and (2) to compare the proportion of breakthrough infection among Covishield and Covaxin recipients. Materials and Methods: The subjects were selected by systematic random sample method from available vaccination record. A questionnaire was administered in local language containing demographic information and COVID-related information. Nasopharyngeal swab was taken by trained Interns with all necessary precautions, RT-PCR swab was labeled and sent to PCR laboratory in cold chain for testing. Results: A total 445 subjects were tested for COVID-19. Subjects included 290 (65.2%) males and 155 (34.8%) females. Maximum cases were from age group of 21–30 year (23.4%). The mean age was found to be 43 year. About 8.85% subjects test result came positive despite taking two doses of either COVID vaccine. Breakthrough infection was more among males than females. Covaxin recipient subjects showed marginally higher percentage of breakthrough infection (9.1%) than Covishield. Out of the 39 breakthrough infections, 16 subjects were having comorbidities. Maximum breakthrough infection was seen in subjects having diabetes mellitus and hypertension both and hypertension alone (1.6%). Conclusion: A prevalence of 8.8% of COVID-19 breakthrough infection was reported in our study among fully vaccinated subjects after 30 days of last vaccine dose. Males are at higher risk of getting infection. People with comorbidities are at higher risk of breakthrough infection and hospitalization.https://www.nepjol.info/index.php/AJMS/article/view/44473breakthrough infectioncomorbiditiescovid-10 vaccinecovid-19 |
| spellingShingle | Sushant S Chavan Madhuri Suryawanshi Vikrant Pagar Sarika P Patil Amol D Kinge COVID-19 breakthrough infection among vaccinated individuals: A cross-sectional study Asian Journal of Medical Sciences breakthrough infection comorbidities covid-10 vaccine covid-19 |
| title | COVID-19 breakthrough infection among vaccinated individuals: A cross-sectional study |
| title_full | COVID-19 breakthrough infection among vaccinated individuals: A cross-sectional study |
| title_fullStr | COVID-19 breakthrough infection among vaccinated individuals: A cross-sectional study |
| title_full_unstemmed | COVID-19 breakthrough infection among vaccinated individuals: A cross-sectional study |
| title_short | COVID-19 breakthrough infection among vaccinated individuals: A cross-sectional study |
| title_sort | covid 19 breakthrough infection among vaccinated individuals a cross sectional study |
| topic | breakthrough infection comorbidities covid-10 vaccine covid-19 |
| url | https://www.nepjol.info/index.php/AJMS/article/view/44473 |
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