Microdevices for Non-Invasive Detection of Bladder Cancer
Bladder cancer holds the record for the highest lifetime cost on a per-patient basis. This is due to high recurrence rates, which necessitate invasive and costly long-term evaluation methods such as cystoscopy and imaging. Microfluidics is emerging as an important approach to contribute to initial d...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Chemosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9040/5/4/30 |
| _version_ | 1818912767782944768 |
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| author | Constantine Tzouanas Joey Sze Yun Lim Ya Wen Jean Paul Thiery Bee Luan Khoo |
| author_facet | Constantine Tzouanas Joey Sze Yun Lim Ya Wen Jean Paul Thiery Bee Luan Khoo |
| author_sort | Constantine Tzouanas |
| collection | DOAJ |
| description | Bladder cancer holds the record for the highest lifetime cost on a per-patient basis. This is due to high recurrence rates, which necessitate invasive and costly long-term evaluation methods such as cystoscopy and imaging. Microfluidics is emerging as an important approach to contribute to initial diagnosis and follow-up, by enabling the precise manipulation of biological samples. Specifically, microdevices have been used for the isolation of cells or genetic material from blood samples, sparking significant interest as a versatile platform for non-invasive bladder cancer detection with voided urine. In this review, we revisit the methods of bladder cancer detection and describe various types of markers currently used for evaluation. We detail cutting-edge technologies and evaluate their merits in the detection, screening, and diagnosis of bladder cancer. Advantages of microscale devices over standard methods of detection, as well as their limitations, are provided. We conclude with a discussion of criteria for guiding microdevice development that could deepen our understanding of prognoses at the level of individual patients and the underlying biology of bladder cancer development. Collectively, the development and widespread application of improved microfluidic devices for bladder cancer could drive treatment breakthroughs and establish widespread, tangible outcomes on patients’ long-term survival. |
| first_indexed | 2024-12-19T23:19:50Z |
| format | Article |
| id | doaj.art-f2aa67f3c3764f1094b992b8a267d24b |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-12-19T23:19:50Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-f2aa67f3c3764f1094b992b8a267d24b2022-12-21T20:02:00ZengMDPI AGChemosensors2227-90402017-11-01543010.3390/chemosensors5040030chemosensors5040030Microdevices for Non-Invasive Detection of Bladder CancerConstantine Tzouanas0Joey Sze Yun Lim1Ya Wen2Jean Paul Thiery3Bee Luan Khoo4Department of Bioengineering, Rice University, Houston, TX 77005, USABioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602, SingaporePlug and Play Tech Center, Sunnyvale, CA 94043, USADepartment of Biochemistry Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeBioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602, SingaporeBladder cancer holds the record for the highest lifetime cost on a per-patient basis. This is due to high recurrence rates, which necessitate invasive and costly long-term evaluation methods such as cystoscopy and imaging. Microfluidics is emerging as an important approach to contribute to initial diagnosis and follow-up, by enabling the precise manipulation of biological samples. Specifically, microdevices have been used for the isolation of cells or genetic material from blood samples, sparking significant interest as a versatile platform for non-invasive bladder cancer detection with voided urine. In this review, we revisit the methods of bladder cancer detection and describe various types of markers currently used for evaluation. We detail cutting-edge technologies and evaluate their merits in the detection, screening, and diagnosis of bladder cancer. Advantages of microscale devices over standard methods of detection, as well as their limitations, are provided. We conclude with a discussion of criteria for guiding microdevice development that could deepen our understanding of prognoses at the level of individual patients and the underlying biology of bladder cancer development. Collectively, the development and widespread application of improved microfluidic devices for bladder cancer could drive treatment breakthroughs and establish widespread, tangible outcomes on patients’ long-term survival.https://www.mdpi.com/2227-9040/5/4/30microdevicesnon-invasive proceduresbladder cancerurine |
| spellingShingle | Constantine Tzouanas Joey Sze Yun Lim Ya Wen Jean Paul Thiery Bee Luan Khoo Microdevices for Non-Invasive Detection of Bladder Cancer Chemosensors microdevices non-invasive procedures bladder cancer urine |
| title | Microdevices for Non-Invasive Detection of Bladder Cancer |
| title_full | Microdevices for Non-Invasive Detection of Bladder Cancer |
| title_fullStr | Microdevices for Non-Invasive Detection of Bladder Cancer |
| title_full_unstemmed | Microdevices for Non-Invasive Detection of Bladder Cancer |
| title_short | Microdevices for Non-Invasive Detection of Bladder Cancer |
| title_sort | microdevices for non invasive detection of bladder cancer |
| topic | microdevices non-invasive procedures bladder cancer urine |
| url | https://www.mdpi.com/2227-9040/5/4/30 |
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