Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates

Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates

Induced pluripotent stem cells (iPSCs) can serve as a source of cardiomyocytes (CMs) to treat end-stage heart failure; however, transplantation of genetically dissimilar iPSCs even within species (allogeneic) can induce immune rejection. We hypothesized that this might be limited by matching the maj...

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Bibliographic Details
Main Authors: Takuji Kawamura, Shigeru Miyagawa, Satsuki Fukushima, Akira Maeda, Noriyuki Kashiyama, Ai Kawamura, Kenji Miki, Keisuke Okita, Yoshinori Yoshida, Takashi Shiina, Kazumasa Ogasawara, Shuji Miyagawa, Koichi Toda, Hiroomi Okuyama, Yoshiki Sawa
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116000291

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