Killing two birds with one stone: Trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria
Within the past decade, remarkable similarities between the molecular organization of animal and plant systems for non-self discrimination were revealed. Obvious parallels exist between the molecular structures of the receptors mediating the recognition of pathogen- or microbe-associated molecular p...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00320/full |
| _version_ | 1828796834487730176 |
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| author | Frederic eBrunner Malou eFraiture |
| author_facet | Frederic eBrunner Malou eFraiture |
| author_sort | Frederic eBrunner |
| collection | DOAJ |
| description | Within the past decade, remarkable similarities between the molecular organization of animal and plant systems for non-self discrimination were revealed. Obvious parallels exist between the molecular structures of the receptors mediating the recognition of pathogen- or microbe-associated molecular patterns (PAMPs/MAMPs) with plant pattern recognition receptors (PRRs) strikingly resembling mammalian Toll-like receptors. Mitogen-activated protein (MAP) kinase cascades, leading to the transcriptional activation of immunity-associated genes, illustrate the conservation of whole molecular building blocks of PAMP/MAMP-induced signaling. Enteropathogenic Salmonella and Escherichia coli use a type three secretion system (T3SS) to inject effector proteins into the mammalian host cell to subvert defense mechanisms and promote gut infection. Lately, disease occurrence was increasingly associated with bacteria-contaminated fruits and vegetables and common themes have emerged with regard to whether and how effectors target innate immune responses in a trans-kingdom manner. We propose that numerous Salmonella or E. coli effectors may be active in planta and tend to target central components (hubs) of immune signaling pathways. |
| first_indexed | 2024-12-12T04:29:48Z |
| format | Article |
| id | doaj.art-f2ab9d95845e4f8ea5f46305b669cd47 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T04:29:48Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-f2ab9d95845e4f8ea5f46305b669cd472022-12-22T00:38:07ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2014-07-01510.3389/fmicb.2014.0032099552Killing two birds with one stone: Trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteriaFrederic eBrunner0Malou eFraiture1Eberhard Karls University TübingenEberhard Karls University TübingenWithin the past decade, remarkable similarities between the molecular organization of animal and plant systems for non-self discrimination were revealed. Obvious parallels exist between the molecular structures of the receptors mediating the recognition of pathogen- or microbe-associated molecular patterns (PAMPs/MAMPs) with plant pattern recognition receptors (PRRs) strikingly resembling mammalian Toll-like receptors. Mitogen-activated protein (MAP) kinase cascades, leading to the transcriptional activation of immunity-associated genes, illustrate the conservation of whole molecular building blocks of PAMP/MAMP-induced signaling. Enteropathogenic Salmonella and Escherichia coli use a type three secretion system (T3SS) to inject effector proteins into the mammalian host cell to subvert defense mechanisms and promote gut infection. Lately, disease occurrence was increasingly associated with bacteria-contaminated fruits and vegetables and common themes have emerged with regard to whether and how effectors target innate immune responses in a trans-kingdom manner. We propose that numerous Salmonella or E. coli effectors may be active in planta and tend to target central components (hubs) of immune signaling pathways.http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00320/fullEscherichia coli O157MammalsPlantsSalmonellainnate immunityPattern Recognition Receptors |
| spellingShingle | Frederic eBrunner Malou eFraiture Killing two birds with one stone: Trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria Frontiers in Microbiology Escherichia coli O157 Mammals Plants Salmonella innate immunity Pattern Recognition Receptors |
| title | Killing two birds with one stone: Trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria |
| title_full | Killing two birds with one stone: Trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria |
| title_fullStr | Killing two birds with one stone: Trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria |
| title_full_unstemmed | Killing two birds with one stone: Trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria |
| title_short | Killing two birds with one stone: Trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria |
| title_sort | killing two birds with one stone trans kingdom suppression of pamp mamp induced immunity by t3e from enteropathogenic bacteria |
| topic | Escherichia coli O157 Mammals Plants Salmonella innate immunity Pattern Recognition Receptors |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00320/full |
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