GSK3β Inhibition Reduced Vascular Calcification in <i>Ins2<sup>Akita/+</sup></i> Mice

GSK3β Inhibition Reduced Vascular Calcification in <i>Ins2<sup>Akita/+</sup></i> Mice

Endothelial–mesenchymal transition (EndMT) drives the endothelium to contribute to vascular calcification in diabetes mellitus. In our previous study, we showed that glycogen synthase kinase-3β (GSK3β) inhibition induces β-catenin and reduces mothers against DPP homolog 1 (SMAD1) to direct osteoblas...

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Bibliographic Details
Main Authors: Kristina I. Boström, Xiaojing Qiao, Yan Zhao, Xiuju Wu, Li Zhang, Jocelyn A. Ma, Jaden Ji, Xinjiang Cai, Yucheng Yao
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
vascular calcification
endothelial cells
diabetes mellitus
glycogen synthase kinase-3β inhibition
Online Access:https://www.mdpi.com/1422-0067/24/6/5971

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https://www.mdpi.com/1422-0067/24/6/5971

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