Physical activity moderates the association between executive function and functional connectivity in older adults
Recent evidence suggests that physical activity may influence the functional connectivity of the aging brain. The purpose of this study was to examine the influence of physical activity on the association between executive function and functional connectivity of key brain networks and graph theory m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Aging Brain |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589958922000081 |
| _version_ | 1811197446511919104 |
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| author | Marissa A Gogniat Talia L Robinson Kharine R Jean L Stephen Miller |
| author_facet | Marissa A Gogniat Talia L Robinson Kharine R Jean L Stephen Miller |
| author_sort | Marissa A Gogniat |
| collection | DOAJ |
| description | Recent evidence suggests that physical activity may influence the functional connectivity of the aging brain. The purpose of this study was to examine the influence of physical activity on the association between executive function and functional connectivity of key brain networks and graph theory metrics in community-dwelling older adults. Participants were 47 older adults (M = 73 years; SD = 5.92) who participated in neuropsychological testing, physical activity measurements, and magnetic resonance imaging (MRI). Seed-to-voxel moderation analyses and graph theory analyses were conducted. Physical activity was significantly positively associated with default mode network functional connectivity (DMN FC; Posterior Cingulate Gyrus, p-FDR = 0.005; Frontal Pole (L), p-FDR = 0.005; Posterior Cingulate Gyrus, p-FDR = 0.006; Superior Frontal Gyrus (L), p-FDR = 0.016) and dorsal attention network functional connectivity (DAN FC; Inferior Frontal Gyrus Pars Opercularis (R), p-FDR = 0.044). The interaction between physical activity and executive function on the DMN FC and DAN FC was analyzed. The interaction between executive function and physical activity was significantly associated with DMN FC. When this significant interaction was probed, the association between physical activity and DMN FC differed between levels of high and low executive function such that the association was only significant at levels of high executive function. These results suggest that greater physical activity in later life is associated with greater DMN and DAN FC and provides evidence for the importance of physical activity in cognitively healthy older adults. |
| first_indexed | 2024-04-12T01:13:48Z |
| format | Article |
| id | doaj.art-f2adee294d5f4dbaa66c92b23469ac7c |
| institution | Directory Open Access Journal |
| issn | 2589-9589 |
| language | English |
| last_indexed | 2024-04-12T01:13:48Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aging Brain |
| spelling | doaj.art-f2adee294d5f4dbaa66c92b23469ac7c2022-12-22T03:54:01ZengElsevierAging Brain2589-95892022-01-012100036Physical activity moderates the association between executive function and functional connectivity in older adultsMarissa A Gogniat0Talia L Robinson1Kharine R Jean2L Stephen Miller3Corresponding author at: 100 Hooper Street, Athens, GA 30602, USA.; University of Georgia, Department of Psychology, Athens, GA, USAUniversity of Georgia, Department of Psychology, Athens, GA, USAUniversity of Georgia, Department of Psychology, Athens, GA, USAUniversity of Georgia, Department of Psychology, Athens, GA, USARecent evidence suggests that physical activity may influence the functional connectivity of the aging brain. The purpose of this study was to examine the influence of physical activity on the association between executive function and functional connectivity of key brain networks and graph theory metrics in community-dwelling older adults. Participants were 47 older adults (M = 73 years; SD = 5.92) who participated in neuropsychological testing, physical activity measurements, and magnetic resonance imaging (MRI). Seed-to-voxel moderation analyses and graph theory analyses were conducted. Physical activity was significantly positively associated with default mode network functional connectivity (DMN FC; Posterior Cingulate Gyrus, p-FDR = 0.005; Frontal Pole (L), p-FDR = 0.005; Posterior Cingulate Gyrus, p-FDR = 0.006; Superior Frontal Gyrus (L), p-FDR = 0.016) and dorsal attention network functional connectivity (DAN FC; Inferior Frontal Gyrus Pars Opercularis (R), p-FDR = 0.044). The interaction between physical activity and executive function on the DMN FC and DAN FC was analyzed. The interaction between executive function and physical activity was significantly associated with DMN FC. When this significant interaction was probed, the association between physical activity and DMN FC differed between levels of high and low executive function such that the association was only significant at levels of high executive function. These results suggest that greater physical activity in later life is associated with greater DMN and DAN FC and provides evidence for the importance of physical activity in cognitively healthy older adults.http://www.sciencedirect.com/science/article/pii/S2589958922000081Physical activityOlder adultsFunctional connectivityGraph theory |
| spellingShingle | Marissa A Gogniat Talia L Robinson Kharine R Jean L Stephen Miller Physical activity moderates the association between executive function and functional connectivity in older adults Aging Brain Physical activity Older adults Functional connectivity Graph theory |
| title | Physical activity moderates the association between executive function and functional connectivity in older adults |
| title_full | Physical activity moderates the association between executive function and functional connectivity in older adults |
| title_fullStr | Physical activity moderates the association between executive function and functional connectivity in older adults |
| title_full_unstemmed | Physical activity moderates the association between executive function and functional connectivity in older adults |
| title_short | Physical activity moderates the association between executive function and functional connectivity in older adults |
| title_sort | physical activity moderates the association between executive function and functional connectivity in older adults |
| topic | Physical activity Older adults Functional connectivity Graph theory |
| url | http://www.sciencedirect.com/science/article/pii/S2589958922000081 |
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