Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population
Abstract Background Autism is a complex neurodevelopmental disorder with high heritability. Zinc finger protein 804A (ZNF804A) was suggested to play important roles in neurodevelopment. Previous studies indicated that single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A was strongly associated...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-05-01
|
| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12888-019-2144-1 |
| _version_ | 1818989468377415680 |
|---|---|
| author | Ziqi Wang Tian Zhang Jing Liu Han Wang Tianlan Lu Meixiang Jia Dai Zhang Lifang Wang Jun Li |
| author_facet | Ziqi Wang Tian Zhang Jing Liu Han Wang Tianlan Lu Meixiang Jia Dai Zhang Lifang Wang Jun Li |
| author_sort | Ziqi Wang |
| collection | DOAJ |
| description | Abstract Background Autism is a complex neurodevelopmental disorder with high heritability. Zinc finger protein 804A (ZNF804A) was suggested to play important roles in neurodevelopment. Previous studies indicated that single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A was strongly associated with schizophrenia and might influence social interaction. Only one study explored the significance of ZNF804A polymorphisms in autism, which discovered that rs7603001 was nominally associated with autism. Moreover, no previous study investigated the association between ZNF804A and autism in a Han Chinese population. Here, we investigated whether these two SNPs (rs1344706 and rs7603001) in ZNF804A contribute to the risk of autism in a Han Chinese population. Methods We performed a family-based association study in 640 Han Chinese autism trios. Sanger sequencing was used for sample genotyping. Then, single marker association analyses were conducted using the family-based association test (FBAT) program. Results No significant association was found between the two SNPs (rs1344706 and rs7603001) in ZNF804A and autism (P > 0.05). Conclusions Our findings suggested that rs1344706 and rs7603001 in ZNF804A might not be associated with autism in a Han Chinese population. |
| first_indexed | 2024-12-20T19:38:57Z |
| format | Article |
| id | doaj.art-f2af1b68509d48bc93376b8901796576 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-20T19:38:57Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-f2af1b68509d48bc93376b89017965762022-12-21T19:28:35ZengBMCBMC Psychiatry1471-244X2019-05-011911610.1186/s12888-019-2144-1Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese populationZiqi Wang0Tian Zhang1Jing Liu2Han Wang3Tianlan Lu4Meixiang Jia5Dai Zhang6Lifang Wang7Jun Li8Peking University Sixth HospitalPeking University Sixth HospitalPeking University Sixth HospitalPeking University Sixth HospitalPeking University Sixth HospitalPeking University Sixth HospitalPeking University Sixth HospitalPeking University Sixth HospitalPeking University Sixth HospitalAbstract Background Autism is a complex neurodevelopmental disorder with high heritability. Zinc finger protein 804A (ZNF804A) was suggested to play important roles in neurodevelopment. Previous studies indicated that single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A was strongly associated with schizophrenia and might influence social interaction. Only one study explored the significance of ZNF804A polymorphisms in autism, which discovered that rs7603001 was nominally associated with autism. Moreover, no previous study investigated the association between ZNF804A and autism in a Han Chinese population. Here, we investigated whether these two SNPs (rs1344706 and rs7603001) in ZNF804A contribute to the risk of autism in a Han Chinese population. Methods We performed a family-based association study in 640 Han Chinese autism trios. Sanger sequencing was used for sample genotyping. Then, single marker association analyses were conducted using the family-based association test (FBAT) program. Results No significant association was found between the two SNPs (rs1344706 and rs7603001) in ZNF804A and autism (P > 0.05). Conclusions Our findings suggested that rs1344706 and rs7603001 in ZNF804A might not be associated with autism in a Han Chinese population.http://link.springer.com/article/10.1186/s12888-019-2144-1AutismZNF804ASingle-nucleotide polymorphismFamily-based association study |
| spellingShingle | Ziqi Wang Tian Zhang Jing Liu Han Wang Tianlan Lu Meixiang Jia Dai Zhang Lifang Wang Jun Li Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population BMC Psychiatry Autism ZNF804A Single-nucleotide polymorphism Family-based association study |
| title | Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population |
| title_full | Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population |
| title_fullStr | Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population |
| title_full_unstemmed | Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population |
| title_short | Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population |
| title_sort | family based association study of znf804a polymorphisms and autism in a han chinese population |
| topic | Autism ZNF804A Single-nucleotide polymorphism Family-based association study |
| url | http://link.springer.com/article/10.1186/s12888-019-2144-1 |
| work_keys_str_mv | AT ziqiwang familybasedassociationstudyofznf804apolymorphismsandautisminahanchinesepopulation AT tianzhang familybasedassociationstudyofznf804apolymorphismsandautisminahanchinesepopulation AT jingliu familybasedassociationstudyofznf804apolymorphismsandautisminahanchinesepopulation AT hanwang familybasedassociationstudyofznf804apolymorphismsandautisminahanchinesepopulation AT tianlanlu familybasedassociationstudyofznf804apolymorphismsandautisminahanchinesepopulation AT meixiangjia familybasedassociationstudyofznf804apolymorphismsandautisminahanchinesepopulation AT daizhang familybasedassociationstudyofznf804apolymorphismsandautisminahanchinesepopulation AT lifangwang familybasedassociationstudyofznf804apolymorphismsandautisminahanchinesepopulation AT junli familybasedassociationstudyofznf804apolymorphismsandautisminahanchinesepopulation |