Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy

Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy

Abstract Hypertensive nephrosclerosis (HN) and Type 2 diabetic nephropathy (T2DN) are the leading causes of chronic kidney disease (CKD). To explore shared pathogenetic mechanisms, we analyzed transcriptomes of kidney biopsies from patients with HN or T2DN. Total RNA was extracted from 10 μm whole k...

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Bibliographic Details
Main Authors: Ole Petter Nordbø, Lea Landolt, Øystein Eikrem, Andreas Scherer, Sabine Leh, Jessica Furriol, Terje Apeland, Piotr Mydel, Hans‐Peter Marti
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Physiological Reports
Subjects:
diabetic nephropathy
hypertensive nephropathy
inflammation
renal transcriptome
Online Access:https://doi.org/10.14814/phy2.15825

Internet

https://doi.org/10.14814/phy2.15825

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