Nanoparticles in the ocular drug delivery
Ocular drug transport barriers pose a challenge for drug delivery comprising the ocular surface epithelium, the tear film and internal barriers of the blood-aqueous and blood-retina barriers. Ocular drug delivery efficiency depends on the barriers and the clearance from the choroidal, conjunctival v...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2013-06-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693026/ |
| _version_ | 1811270647089725440 |
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| author | Wen-Song Zhang Yu Zheng Shuang Wang Ji-Long Hao Hong-Yan Zhou |
| author_facet | Wen-Song Zhang Yu Zheng Shuang Wang Ji-Long Hao Hong-Yan Zhou |
| author_sort | Wen-Song Zhang |
| collection | DOAJ |
| description | Ocular drug transport barriers pose a challenge for drug delivery comprising the ocular surface epithelium, the tear film and internal barriers of the blood-aqueous and blood-retina barriers. Ocular drug delivery efficiency depends on the barriers and the clearance from the choroidal, conjunctival vessels and lymphatic. Traditional drug administration reduces the clinical efficacy especially for poor water soluble molecules and for the posterior segment of the eye. Nanoparticles (NPs) have been designed to overcome the barriers, increase the drug penetration at the target site and prolong the drug levels by few internals of drug administrations in lower doses without any toxicity compared to the conventional eye drops. With the aid of high specificity and multifunctionality, DNA NPs can be resulted in higher transfection efficiency for gene therapy. NPs could target at cornea, retina and choroid by surficial applications and intravitreal injection. This review is concerned with recent findings and applications of NPs drug delivery systems for the treatment of different eye diseases. |
| first_indexed | 2024-04-12T22:05:52Z |
| format | Article |
| id | doaj.art-f2b1dd1871e54b269c7d9c1702f8f5fb |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-12T22:05:52Z |
| publishDate | 2013-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-f2b1dd1871e54b269c7d9c1702f8f5fb2022-12-22T03:14:58ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982013-06-016339039610.3980/j.issn.2222-3959.2013.03.25Nanoparticles in the ocular drug deliveryWen-Song ZhangYu ZhengShuang WangJi-Long HaoHong-Yan ZhouOcular drug transport barriers pose a challenge for drug delivery comprising the ocular surface epithelium, the tear film and internal barriers of the blood-aqueous and blood-retina barriers. Ocular drug delivery efficiency depends on the barriers and the clearance from the choroidal, conjunctival vessels and lymphatic. Traditional drug administration reduces the clinical efficacy especially for poor water soluble molecules and for the posterior segment of the eye. Nanoparticles (NPs) have been designed to overcome the barriers, increase the drug penetration at the target site and prolong the drug levels by few internals of drug administrations in lower doses without any toxicity compared to the conventional eye drops. With the aid of high specificity and multifunctionality, DNA NPs can be resulted in higher transfection efficiency for gene therapy. NPs could target at cornea, retina and choroid by surficial applications and intravitreal injection. This review is concerned with recent findings and applications of NPs drug delivery systems for the treatment of different eye diseases.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693026/nanoparticleseyedrug delivery |
| spellingShingle | Wen-Song Zhang Yu Zheng Shuang Wang Ji-Long Hao Hong-Yan Zhou Nanoparticles in the ocular drug delivery International Journal of Ophthalmology nanoparticles eye drug delivery |
| title | Nanoparticles in the ocular drug delivery |
| title_full | Nanoparticles in the ocular drug delivery |
| title_fullStr | Nanoparticles in the ocular drug delivery |
| title_full_unstemmed | Nanoparticles in the ocular drug delivery |
| title_short | Nanoparticles in the ocular drug delivery |
| title_sort | nanoparticles in the ocular drug delivery |
| topic | nanoparticles eye drug delivery |
| url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693026/ |
| work_keys_str_mv | AT wensongzhang nanoparticlesintheoculardrugdelivery AT yuzheng nanoparticlesintheoculardrugdelivery AT shuangwang nanoparticlesintheoculardrugdelivery AT jilonghao nanoparticlesintheoculardrugdelivery AT hongyanzhou nanoparticlesintheoculardrugdelivery |