When to perform bone scintigraphy in patients with newly diagnosed prostate cancer? a retrospective study
Abstract Background To determine when a bone scintigraphy investigation is appropriate in patients with newly diagnosed prostate cancer (PCa). Methods We retrospectively reviewed 703 newly diagnosed PCa patients who were referred for bone scintigraphy. The association between age, prostate specific...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | BMC Urology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12894-017-0229-z |
| _version_ | 1819135825131077632 |
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| author | Yiwei Lin Qiqi Mao Bin Chen Liujiang Wang Ben Liu Xiangyi Zheng Liping Xie |
| author_facet | Yiwei Lin Qiqi Mao Bin Chen Liujiang Wang Ben Liu Xiangyi Zheng Liping Xie |
| author_sort | Yiwei Lin |
| collection | DOAJ |
| description | Abstract Background To determine when a bone scintigraphy investigation is appropriate in patients with newly diagnosed prostate cancer (PCa). Methods We retrospectively reviewed 703 newly diagnosed PCa patients who were referred for bone scintigraphy. The association between age, prostate specific antigen (PSA), Gleason score (GS) and bone scintigraphy result were investigated by series of crude or stratified analysis. Results Overall, 15.08% (106/703) patients had bone metastases. PSA and GS between positive bone scan group and negative bone scan group were significantly different, while age was not. The incidence of bone metastasis in patient with PSA < 20 ng/ml or GS < 8 was less than 10%, but increased dramatically with rising PSA and upgrading GS. In multivariate analysis, PSA ≥ 20 ng/ml (OR = 5.10, 95%CI (2.12-12.27)) and GS ≥ 8 (OR = 3.61, 95%CI (1.55-8.41)) were independently predictive of positive bone scan. Conclusions Patients with PSA ≥ 20 ng/ml or GS ≥ 8 were in higher risk of bone metastasis, bone scintigraphy was recommended. But a bone scintigraphy is of limited value in PCa patients with PSA ≤ 20 ng/ml and GS ≤ 7. |
| first_indexed | 2024-12-22T10:25:14Z |
| format | Article |
| id | doaj.art-f2b22ebec4d847719517119338dee8f3 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-12-22T10:25:14Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-f2b22ebec4d847719517119338dee8f32022-12-21T18:29:30ZengBMCBMC Urology1471-24902017-06-011711510.1186/s12894-017-0229-zWhen to perform bone scintigraphy in patients with newly diagnosed prostate cancer? a retrospective studyYiwei Lin0Qiqi Mao1Bin Chen2Liujiang Wang3Ben Liu4Xiangyi Zheng5Liping Xie6Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityAbstract Background To determine when a bone scintigraphy investigation is appropriate in patients with newly diagnosed prostate cancer (PCa). Methods We retrospectively reviewed 703 newly diagnosed PCa patients who were referred for bone scintigraphy. The association between age, prostate specific antigen (PSA), Gleason score (GS) and bone scintigraphy result were investigated by series of crude or stratified analysis. Results Overall, 15.08% (106/703) patients had bone metastases. PSA and GS between positive bone scan group and negative bone scan group were significantly different, while age was not. The incidence of bone metastasis in patient with PSA < 20 ng/ml or GS < 8 was less than 10%, but increased dramatically with rising PSA and upgrading GS. In multivariate analysis, PSA ≥ 20 ng/ml (OR = 5.10, 95%CI (2.12-12.27)) and GS ≥ 8 (OR = 3.61, 95%CI (1.55-8.41)) were independently predictive of positive bone scan. Conclusions Patients with PSA ≥ 20 ng/ml or GS ≥ 8 were in higher risk of bone metastasis, bone scintigraphy was recommended. But a bone scintigraphy is of limited value in PCa patients with PSA ≤ 20 ng/ml and GS ≤ 7.http://link.springer.com/article/10.1186/s12894-017-0229-zProstate cancerProstate specific antigenGleason scoreBone scintigraphy |
| spellingShingle | Yiwei Lin Qiqi Mao Bin Chen Liujiang Wang Ben Liu Xiangyi Zheng Liping Xie When to perform bone scintigraphy in patients with newly diagnosed prostate cancer? a retrospective study BMC Urology Prostate cancer Prostate specific antigen Gleason score Bone scintigraphy |
| title | When to perform bone scintigraphy in patients with newly diagnosed prostate cancer? a retrospective study |
| title_full | When to perform bone scintigraphy in patients with newly diagnosed prostate cancer? a retrospective study |
| title_fullStr | When to perform bone scintigraphy in patients with newly diagnosed prostate cancer? a retrospective study |
| title_full_unstemmed | When to perform bone scintigraphy in patients with newly diagnosed prostate cancer? a retrospective study |
| title_short | When to perform bone scintigraphy in patients with newly diagnosed prostate cancer? a retrospective study |
| title_sort | when to perform bone scintigraphy in patients with newly diagnosed prostate cancer a retrospective study |
| topic | Prostate cancer Prostate specific antigen Gleason score Bone scintigraphy |
| url | http://link.springer.com/article/10.1186/s12894-017-0229-z |
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