Research on soluble VEGF receptor 1 in retinal neovascularization
The common feature of retinal neovascularization is the formation of pathological neovascularization. The primary one of endogenous retinal neovascularization factor in current research is vascular endothelial growth factor(VEGF). SFlt-1, the soluble form of splicing in mRNA extracellular region of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2018-03-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2018/4/201804013.pdf |
| _version_ | 1819169222481149952 |
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| author | Xiao-Yuan Cui Guo-Xing Xu |
| author_facet | Xiao-Yuan Cui Guo-Xing Xu |
| author_sort | Xiao-Yuan Cui |
| collection | DOAJ |
| description | The common feature of retinal neovascularization is the formation of pathological neovascularization. The primary one of endogenous retinal neovascularization factor in current research is vascular endothelial growth factor(VEGF). SFlt-1, the soluble form of splicing in mRNA extracellular region of VEGFR-1, which is short of intracellular tyrosine kinase domain can only encode the extracellular domain. Therefore, it only can bind with ligands but can not transmit signals, thus preventing the formation of neovascularization. SFlt-1, as a hot research topic in recent years, may provide a new gene therapy method for this disease. This review focus on the mechanism and research progress of sFlt-1 in retinal neovascularization. |
| first_indexed | 2024-12-22T19:16:04Z |
| format | Article |
| id | doaj.art-f2b7b8017c5b44b8840093f860519b80 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-22T19:16:04Z |
| publishDate | 2018-03-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-f2b7b8017c5b44b8840093f860519b802022-12-21T18:15:31ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232018-03-0118464965110.3980/j.issn.1672-5123.2018.4.13Research on soluble VEGF receptor 1 in retinal neovascularizationXiao-Yuan Cui0Guo-Xing Xu1Fujian Institute of Ophthalmology; Department of Ophthalmology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, ChinaFujian Institute of Ophthalmology; Department of Ophthalmology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, ChinaThe common feature of retinal neovascularization is the formation of pathological neovascularization. The primary one of endogenous retinal neovascularization factor in current research is vascular endothelial growth factor(VEGF). SFlt-1, the soluble form of splicing in mRNA extracellular region of VEGFR-1, which is short of intracellular tyrosine kinase domain can only encode the extracellular domain. Therefore, it only can bind with ligands but can not transmit signals, thus preventing the formation of neovascularization. SFlt-1, as a hot research topic in recent years, may provide a new gene therapy method for this disease. This review focus on the mechanism and research progress of sFlt-1 in retinal neovascularization.http://ies.ijo.cn/cn_publish/2018/4/201804013.pdfvascular endothelial growth factorsoluble vascular endothelial growth factor receptor 1retinal neovascularizationretinal neovascularization |
| spellingShingle | Xiao-Yuan Cui Guo-Xing Xu Research on soluble VEGF receptor 1 in retinal neovascularization Guoji Yanke Zazhi vascular endothelial growth factor soluble vascular endothelial growth factor receptor 1 retinal neovascularization retinal neovascularization |
| title | Research on soluble VEGF receptor 1 in retinal neovascularization |
| title_full | Research on soluble VEGF receptor 1 in retinal neovascularization |
| title_fullStr | Research on soluble VEGF receptor 1 in retinal neovascularization |
| title_full_unstemmed | Research on soluble VEGF receptor 1 in retinal neovascularization |
| title_short | Research on soluble VEGF receptor 1 in retinal neovascularization |
| title_sort | research on soluble vegf receptor 1 in retinal neovascularization |
| topic | vascular endothelial growth factor soluble vascular endothelial growth factor receptor 1 retinal neovascularization retinal neovascularization |
| url | http://ies.ijo.cn/cn_publish/2018/4/201804013.pdf |
| work_keys_str_mv | AT xiaoyuancui researchonsolublevegfreceptor1inretinalneovascularization AT guoxingxu researchonsolublevegfreceptor1inretinalneovascularization |