DnaJC7 specifically regulates tau seeding

DnaJC7 specifically regulates tau seeding

Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate. Several large families of chaperone proteins, including Hsp70s and J doma...

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Bibliographic Details
Main Authors: Valerie Ann Perez, David W Sanders, Ayde Mendoza-Oliva, Barbara Elena Stopschinski, Vishruth Mullapudi, Charles L White, Lukasz A Joachimiak, Marc I Diamond
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
tau
chaperones
seeding
amyloid
DnaJC7
J domain protein
Online Access:https://elifesciences.org/articles/86936

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