Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys
<p>Abstract</p> <p>Breast milk transmission remains a major mode of infant HIV acquisition, yet anatomic and immunologic forces shaping virus quasispecies in milk are not well characterized. In this study, phylogenic analysis of envelope sequences of milk SIV variants revealed grou...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-02-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/7/1/7 |
| _version_ | 1818750077439574016 |
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| author | Mansfield Keith G Carville Angela Mach Linh V Wilks Andrew B Kang Helen H Permar Sallie R Learn Gerald H Hahn Beatrice H Letvin Norman L |
| author_facet | Mansfield Keith G Carville Angela Mach Linh V Wilks Andrew B Kang Helen H Permar Sallie R Learn Gerald H Hahn Beatrice H Letvin Norman L |
| author_sort | Mansfield Keith G |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Breast milk transmission remains a major mode of infant HIV acquisition, yet anatomic and immunologic forces shaping virus quasispecies in milk are not well characterized. In this study, phylogenic analysis of envelope sequences of milk SIV variants revealed groups of nearly identical viruses, indicating local virus production. However, comparison of the patterns and rates of CTL escape of blood and milk virus demonstrated only subtle differences between the compartments. These findings suggest that a substantial fraction of milk viruses are produced by locally-infected cells, but are shaped by cellular immune pressures similar to that in the blood.</p> |
| first_indexed | 2024-12-18T04:13:56Z |
| format | Article |
| id | doaj.art-f2bad37335894a4680860951c43a3fa8 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-12-18T04:13:56Z |
| publishDate | 2010-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-f2bad37335894a4680860951c43a3fa82022-12-21T21:21:25ZengBMCRetrovirology1742-46902010-02-0171710.1186/1742-4690-7-7Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeysMansfield Keith GCarville AngelaMach Linh VWilks Andrew BKang Helen HPermar Sallie RLearn Gerald HHahn Beatrice HLetvin Norman L<p>Abstract</p> <p>Breast milk transmission remains a major mode of infant HIV acquisition, yet anatomic and immunologic forces shaping virus quasispecies in milk are not well characterized. In this study, phylogenic analysis of envelope sequences of milk SIV variants revealed groups of nearly identical viruses, indicating local virus production. However, comparison of the patterns and rates of CTL escape of blood and milk virus demonstrated only subtle differences between the compartments. These findings suggest that a substantial fraction of milk viruses are produced by locally-infected cells, but are shaped by cellular immune pressures similar to that in the blood.</p>http://www.retrovirology.com/content/7/1/7 |
| spellingShingle | Mansfield Keith G Carville Angela Mach Linh V Wilks Andrew B Kang Helen H Permar Sallie R Learn Gerald H Hahn Beatrice H Letvin Norman L Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys Retrovirology |
| title | Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys |
| title_full | Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys |
| title_fullStr | Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys |
| title_full_unstemmed | Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys |
| title_short | Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys |
| title_sort | local replication of simian immunodeficiency virus in the breast milk compartment of chronically infected lactating rhesus monkeys |
| url | http://www.retrovirology.com/content/7/1/7 |
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