Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia

Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia

Previous studies have shown that inhibition of TNF family member FN14 (gene: <i>TNFRSF12A</i>) in colon tumors decreases inflammatory cytokine expression and mitigates cancer-induced cachexia. However, the molecular mechanisms underlying the regulation of FN14 expression remain unclear....

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Bibliographic Details
Main Authors: Bryan I. Ruiz, Xazmin H. Lowman, Ying Yang, Qi Fan, Tianhong Wang, Hongmei Wu, Eric A. Hanse, Mei Kong
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Genes
Subjects:
cancer
cachexia
colon cancer
FN14
<i>TNFRSF12A</i>
alpha-ketoglutarate
Online Access:https://www.mdpi.com/2073-4425/14/9/1818

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