The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination
Homologous recombination (HR) is essential for meiosis in most sexually reproducing organisms, where it is induced upon entry into meiotic prophase. Meiotic HR is conducted by the collaborative effort of proteins responsible for DNA double-strand break repair and those produced specifically during m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/4/662 |
| _version_ | 1797606250848976896 |
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| author | Hideo Tsubouchi |
| author_facet | Hideo Tsubouchi |
| author_sort | Hideo Tsubouchi |
| collection | DOAJ |
| description | Homologous recombination (HR) is essential for meiosis in most sexually reproducing organisms, where it is induced upon entry into meiotic prophase. Meiotic HR is conducted by the collaborative effort of proteins responsible for DNA double-strand break repair and those produced specifically during meiosis. The Hop2-Mnd1 complex was originally identified as a meiosis-specific factor that is indispensable for successful meiosis in budding yeast. Later, it was found that Hop2-Mnd1 is conserved from yeasts to humans, playing essential roles in meiosis. Accumulating evidence suggests that Hop2-Mnd1 promotes RecA-like recombinases towards homology search/strand exchange. This review summarizes studies on the mechanism of the Hop2-Mnd1 complex in promoting HR and beyond. |
| first_indexed | 2024-03-11T05:12:32Z |
| format | Article |
| id | doaj.art-f2bbe79913fb4b93b158a5ce3de6caea |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T05:12:32Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-f2bbe79913fb4b93b158a5ce3de6caea2023-11-17T18:29:35ZengMDPI AGBiomolecules2218-273X2023-04-0113466210.3390/biom13040662The Hop2-Mnd1 Complex and Its Regulation of Homologous RecombinationHideo Tsubouchi0Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Kanagawa, JapanHomologous recombination (HR) is essential for meiosis in most sexually reproducing organisms, where it is induced upon entry into meiotic prophase. Meiotic HR is conducted by the collaborative effort of proteins responsible for DNA double-strand break repair and those produced specifically during meiosis. The Hop2-Mnd1 complex was originally identified as a meiosis-specific factor that is indispensable for successful meiosis in budding yeast. Later, it was found that Hop2-Mnd1 is conserved from yeasts to humans, playing essential roles in meiosis. Accumulating evidence suggests that Hop2-Mnd1 promotes RecA-like recombinases towards homology search/strand exchange. This review summarizes studies on the mechanism of the Hop2-Mnd1 complex in promoting HR and beyond.https://www.mdpi.com/2218-273X/13/4/662Dmc1homologous recombinationmeiosisRad51RecA homologssynaptonemal complex |
| spellingShingle | Hideo Tsubouchi The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination Biomolecules Dmc1 homologous recombination meiosis Rad51 RecA homologs synaptonemal complex |
| title | The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination |
| title_full | The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination |
| title_fullStr | The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination |
| title_full_unstemmed | The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination |
| title_short | The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination |
| title_sort | hop2 mnd1 complex and its regulation of homologous recombination |
| topic | Dmc1 homologous recombination meiosis Rad51 RecA homologs synaptonemal complex |
| url | https://www.mdpi.com/2218-273X/13/4/662 |
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