Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic. Of particular interest for this topic are the signaling cascades that regulate cell survival and death, two opposite cell programs whose control...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-10-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-022-05250-5 |
| _version_ | 1797996046458028032 |
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| author | Mariana Suaya Gonzalo Manuel Sánchez Antonella Vila Analía Amante María Cotarelo Mercedes García Carrillo Matías Blaustein |
| author_facet | Mariana Suaya Gonzalo Manuel Sánchez Antonella Vila Analía Amante María Cotarelo Mercedes García Carrillo Matías Blaustein |
| author_sort | Mariana Suaya |
| collection | DOAJ |
| description | Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic. Of particular interest for this topic are the signaling cascades that regulate cell survival and death, two opposite cell programs whose control is hijacked by viral infections. The AKT and the Unfolded Protein Response (UPR) pathways, which maintain cell homeostasis by regulating these two programs, have been shown to be deregulated during SARS-CoVs infection as well as in the development of cancer, one of the most important comorbidities in relation to COVID-19. Recent evidence revealed two way crosstalk mechanisms between the AKT and the UPR pathways, suggesting that they might constitute a unified homeostatic control system. Here, we review the role of the AKT and UPR pathways and their interaction in relation to SARS-CoV-2 infection as well as in tumor onset and progression. Feedback regulation between AKT and UPR pathways emerges as a master control mechanism of cell decision making in terms of survival or death and therefore represents a key potential target for developing treatments for both viral infection and cancer. In particular, drug repositioning, the investigation of existing drugs for new therapeutic purposes, could significantly reduce time and costs compared to de novo drug discovery. |
| first_indexed | 2024-04-11T10:11:14Z |
| format | Article |
| id | doaj.art-f2c0f3738eab416e999a95115e5e6033 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-11T10:11:14Z |
| publishDate | 2022-10-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-f2c0f3738eab416e999a95115e5e60332022-12-22T04:30:06ZengNature Publishing GroupCell Death and Disease2041-48892022-10-01131011510.1038/s41419-022-05250-5Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancerMariana Suaya0Gonzalo Manuel Sánchez1Antonella Vila2Analía Amante3María Cotarelo4Mercedes García Carrillo5Matías Blaustein6Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales (FCEN), Universidad de Buenos Aires (UBA)Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales (FCEN), Universidad de Buenos Aires (UBA)Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales (FCEN), Universidad de Buenos Aires (UBA)Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales (FCEN), Universidad de Buenos Aires (UBA)Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales (FCEN), Universidad de Buenos Aires (UBA)Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales (FCEN), Universidad de Buenos Aires (UBA)Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales (FCEN), Universidad de Buenos Aires (UBA)Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic. Of particular interest for this topic are the signaling cascades that regulate cell survival and death, two opposite cell programs whose control is hijacked by viral infections. The AKT and the Unfolded Protein Response (UPR) pathways, which maintain cell homeostasis by regulating these two programs, have been shown to be deregulated during SARS-CoVs infection as well as in the development of cancer, one of the most important comorbidities in relation to COVID-19. Recent evidence revealed two way crosstalk mechanisms between the AKT and the UPR pathways, suggesting that they might constitute a unified homeostatic control system. Here, we review the role of the AKT and UPR pathways and their interaction in relation to SARS-CoV-2 infection as well as in tumor onset and progression. Feedback regulation between AKT and UPR pathways emerges as a master control mechanism of cell decision making in terms of survival or death and therefore represents a key potential target for developing treatments for both viral infection and cancer. In particular, drug repositioning, the investigation of existing drugs for new therapeutic purposes, could significantly reduce time and costs compared to de novo drug discovery.https://doi.org/10.1038/s41419-022-05250-5 |
| spellingShingle | Mariana Suaya Gonzalo Manuel Sánchez Antonella Vila Analía Amante María Cotarelo Mercedes García Carrillo Matías Blaustein Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer Cell Death and Disease |
| title | Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer |
| title_full | Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer |
| title_fullStr | Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer |
| title_full_unstemmed | Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer |
| title_short | Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer |
| title_sort | live and let die signaling aktivation and upregulation dynamics in sars covs infection and cancer |
| url | https://doi.org/10.1038/s41419-022-05250-5 |
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