CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms?
Frontotemporal Dementia (FTD) encompasses distinct pathophysiologically heterogenous disorders with different genetic and cellular disease mechanisms. The objective of this study is to compare the constellation of biomarkers of neurodegeneration in the cerebrospinal fluid (CSF) to the FTD type categ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00504/full |
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| author | Peter Körtvelyessy Peter Körtvelyessy Hans J. Heinze Hans J. Heinze Hans J. Heinze Johannes Prudlo Johannes Prudlo Daniel Bittner Daniel Bittner |
| author_facet | Peter Körtvelyessy Peter Körtvelyessy Hans J. Heinze Hans J. Heinze Hans J. Heinze Johannes Prudlo Johannes Prudlo Daniel Bittner Daniel Bittner |
| author_sort | Peter Körtvelyessy |
| collection | DOAJ |
| description | Frontotemporal Dementia (FTD) encompasses distinct pathophysiologically heterogenous disorders with different genetic and cellular disease mechanisms. The objective of this study is to compare the constellation of biomarkers of neurodegeneration in the cerebrospinal fluid (CSF) to the FTD type categorized by clinical symptoms. We investigated the levels of Phospho181-tau, Total-tau, Beta-amyloid1−42, Neurofilament light chain, and Progranulin in the CSF of n = 99 FTD patients regarding to the different subtypes of FTD, including semantic dementia (SD), progressive non-fluent aphasia (PNFA), behavioral variant FTD (bvFTD). We compared these groups to patients without neurodegenerative disorders and another cohort encompassing tauopathies with distinct clinical syndromes (Cortico basal syndrome and progressive supranuclear palsy) and logopenic PNFA (lPPA) as another disorder with predominant speech disturbance. CSF-Progranulin levels were significantly lower in FTD type patients with semantic dementia and behavioral variant FTD mainly attributed to the Tar-DNA-Binding-Protein (TDP) 43 compared to predominantly Tau-mediated PNFA (p < 0.05). Also, neurofilament light chain was significantly higher (p < 0.036) in all FTD patients especially in SD patients (p < 0.01). CSF-Nfl levels also distinguished SD patients from logopenic Alzheimers patients (p < 0.05). In sum, CSF-Neurofilament light chain and CSF-Progranulin seem to be promising biomarkers for FTD, the latter predominantly for assumed TDP43-mediated FTD. |
| first_indexed | 2024-12-23T11:06:30Z |
| format | Article |
| id | doaj.art-f2c15b201e684606b3552a4c8347a826 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-23T11:06:30Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-f2c15b201e684606b3552a4c8347a8262022-12-21T17:49:28ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-07-01910.3389/fneur.2018.00504344842CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms?Peter Körtvelyessy0Peter Körtvelyessy1Hans J. Heinze2Hans J. Heinze3Hans J. Heinze4Johannes Prudlo5Johannes Prudlo6Daniel Bittner7Daniel Bittner8Department of Neurology, University Hospital Magdeburg, Magdeburg, GermanyGerman Center for Neurodegenerative Diseases, Magdeburg, GermanyDepartment of Neurology, University Hospital Magdeburg, Magdeburg, GermanyGerman Center for Neurodegenerative Diseases, Magdeburg, GermanyLeibniz Institute for Neurobiology, Magdeburg, GermanyGerman Center for Neurodegenerative Diseases, Rostock, GermanyDepartment of Neurology, University Hospital Rostock, Rostock, GermanyDepartment of Neurology, University Hospital Magdeburg, Magdeburg, GermanyGerman Center for Neurodegenerative Diseases, Magdeburg, GermanyFrontotemporal Dementia (FTD) encompasses distinct pathophysiologically heterogenous disorders with different genetic and cellular disease mechanisms. The objective of this study is to compare the constellation of biomarkers of neurodegeneration in the cerebrospinal fluid (CSF) to the FTD type categorized by clinical symptoms. We investigated the levels of Phospho181-tau, Total-tau, Beta-amyloid1−42, Neurofilament light chain, and Progranulin in the CSF of n = 99 FTD patients regarding to the different subtypes of FTD, including semantic dementia (SD), progressive non-fluent aphasia (PNFA), behavioral variant FTD (bvFTD). We compared these groups to patients without neurodegenerative disorders and another cohort encompassing tauopathies with distinct clinical syndromes (Cortico basal syndrome and progressive supranuclear palsy) and logopenic PNFA (lPPA) as another disorder with predominant speech disturbance. CSF-Progranulin levels were significantly lower in FTD type patients with semantic dementia and behavioral variant FTD mainly attributed to the Tar-DNA-Binding-Protein (TDP) 43 compared to predominantly Tau-mediated PNFA (p < 0.05). Also, neurofilament light chain was significantly higher (p < 0.036) in all FTD patients especially in SD patients (p < 0.01). CSF-Nfl levels also distinguished SD patients from logopenic Alzheimers patients (p < 0.05). In sum, CSF-Neurofilament light chain and CSF-Progranulin seem to be promising biomarkers for FTD, the latter predominantly for assumed TDP43-mediated FTD.https://www.frontiersin.org/article/10.3389/fneur.2018.00504/fullfrontotemporal dementiacerebrospinal fluidphospho-tautauamyloid betaprogranulin |
| spellingShingle | Peter Körtvelyessy Peter Körtvelyessy Hans J. Heinze Hans J. Heinze Hans J. Heinze Johannes Prudlo Johannes Prudlo Daniel Bittner Daniel Bittner CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms? Frontiers in Neurology frontotemporal dementia cerebrospinal fluid phospho-tau tau amyloid beta progranulin |
| title | CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms? |
| title_full | CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms? |
| title_fullStr | CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms? |
| title_full_unstemmed | CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms? |
| title_short | CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms? |
| title_sort | csf biomarkers of neurodegeneration in progressive non fluent aphasia and other forms of frontotemporal dementia clues for pathomechanisms |
| topic | frontotemporal dementia cerebrospinal fluid phospho-tau tau amyloid beta progranulin |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00504/full |
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