Effects of palm bunch potash, trona and their modified cashew gum-corn starch composite on the physicochemical properties of furosemide
Context: In Nigeria, traditional cuisines are prepared using either palm bunch ash (PBA) or trona to impart emulsification, tenderizing and flavouring attributes to oils, proteins and polysaccharides in delicacies. Hypothesis is that they may improve the solubility and dissolution profiles of poorly...
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| Format: | Article |
| Language: | English |
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GarVal Editorial Ltda.
2017-02-01
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| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | http://jppres.com/jppres/pdf/vol5/jppres16.145_5.1.15.pdf |
| _version_ | 1811321888712949760 |
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| author | Ebere I. Okoye Austinline C. Ekweogu Ugochukwu E. Oruna |
| author_facet | Ebere I. Okoye Austinline C. Ekweogu Ugochukwu E. Oruna |
| author_sort | Ebere I. Okoye |
| collection | DOAJ |
| description | Context: In Nigeria, traditional cuisines are prepared using either palm bunch ash (PBA) or trona to impart emulsification, tenderizing and flavouring attributes to oils, proteins and polysaccharides in delicacies. Hypothesis is that they may improve the solubility and dissolution profiles of poorly soluble and permeable drug as furosemide.
Aims: To investigate the effects of palm bunch potash (PBP), trona and modified cashew gum-corn starch composite on the physicochemical properties of furosemide.
Methods: To generate PBP and purified trona, PBA or powdered trona was dispersed in water, filtered, centrifuged and supernatant evaporated to dryness. Cashew gum (CG) and cashew gum-corn starch composite (EC) were modified by mixing with PBP or trona at 5:1 and 10:1, wetted with water, stored in amber vials for 72 h. Furosemide was granulated with modified excipients at 1:1 ratio and characterized: FTIR, DSC, solubility and dissolution studies.
Results: Yield of PBP: 9.38 ± 1.24%, trona: 24.18 ± 0.93%. FTIR spectra of furosemide/granules were similar and retained key functional groups present in furosemide. Their DSC thermograms revealed complete amorphization of furosemide in granules. Mixing of PBP or trona and excipients at 5:1 ratio significantly (p<0.05) improved furosemide’s solubility in comparison to 10:1. Excipient-trona was a significantly (p<0.05) better enhancer of furosemide’s solubility than excipient-PBP. Modified excipients significantly (p<0.05) improved furosemide’s dissolution profile, while unmodified cashew gum reduced it by 50%. Dissolution profile improvement by modified excipients ranked in the order: CG-Trona > CG-PBP > EC-Trona > EC-PBP.
Conclusions: Trona, PBP, modified excipients positively altered the physicopharmaceutical properties of furosemide. |
| first_indexed | 2024-04-13T13:25:33Z |
| format | Article |
| id | doaj.art-f2c2ad194b9a4a4baf4d963bcfc23abd |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-04-13T13:25:33Z |
| publishDate | 2017-02-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-f2c2ad194b9a4a4baf4d963bcfc23abd2022-12-22T02:45:11ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502017-02-01511528Effects of palm bunch potash, trona and their modified cashew gum-corn starch composite on the physicochemical properties of furosemideEbere I. Okoye0Austinline C. Ekweogu1Ugochukwu E. Oruna2Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.Context: In Nigeria, traditional cuisines are prepared using either palm bunch ash (PBA) or trona to impart emulsification, tenderizing and flavouring attributes to oils, proteins and polysaccharides in delicacies. Hypothesis is that they may improve the solubility and dissolution profiles of poorly soluble and permeable drug as furosemide. Aims: To investigate the effects of palm bunch potash (PBP), trona and modified cashew gum-corn starch composite on the physicochemical properties of furosemide. Methods: To generate PBP and purified trona, PBA or powdered trona was dispersed in water, filtered, centrifuged and supernatant evaporated to dryness. Cashew gum (CG) and cashew gum-corn starch composite (EC) were modified by mixing with PBP or trona at 5:1 and 10:1, wetted with water, stored in amber vials for 72 h. Furosemide was granulated with modified excipients at 1:1 ratio and characterized: FTIR, DSC, solubility and dissolution studies. Results: Yield of PBP: 9.38 ± 1.24%, trona: 24.18 ± 0.93%. FTIR spectra of furosemide/granules were similar and retained key functional groups present in furosemide. Their DSC thermograms revealed complete amorphization of furosemide in granules. Mixing of PBP or trona and excipients at 5:1 ratio significantly (p<0.05) improved furosemide’s solubility in comparison to 10:1. Excipient-trona was a significantly (p<0.05) better enhancer of furosemide’s solubility than excipient-PBP. Modified excipients significantly (p<0.05) improved furosemide’s dissolution profile, while unmodified cashew gum reduced it by 50%. Dissolution profile improvement by modified excipients ranked in the order: CG-Trona > CG-PBP > EC-Trona > EC-PBP. Conclusions: Trona, PBP, modified excipients positively altered the physicopharmaceutical properties of furosemide.http://jppres.com/jppres/pdf/vol5/jppres16.145_5.1.15.pdfcashew gum-corn starch compositefurosemidepalm bunch potashsolubility and dissolution improvementtrona |
| spellingShingle | Ebere I. Okoye Austinline C. Ekweogu Ugochukwu E. Oruna Effects of palm bunch potash, trona and their modified cashew gum-corn starch composite on the physicochemical properties of furosemide Journal of Pharmacy & Pharmacognosy Research cashew gum-corn starch composite furosemide palm bunch potash solubility and dissolution improvement trona |
| title | Effects of palm bunch potash, trona and their modified cashew gum-corn starch composite on the physicochemical properties of furosemide |
| title_full | Effects of palm bunch potash, trona and their modified cashew gum-corn starch composite on the physicochemical properties of furosemide |
| title_fullStr | Effects of palm bunch potash, trona and their modified cashew gum-corn starch composite on the physicochemical properties of furosemide |
| title_full_unstemmed | Effects of palm bunch potash, trona and their modified cashew gum-corn starch composite on the physicochemical properties of furosemide |
| title_short | Effects of palm bunch potash, trona and their modified cashew gum-corn starch composite on the physicochemical properties of furosemide |
| title_sort | effects of palm bunch potash trona and their modified cashew gum corn starch composite on the physicochemical properties of furosemide |
| topic | cashew gum-corn starch composite furosemide palm bunch potash solubility and dissolution improvement trona |
| url | http://jppres.com/jppres/pdf/vol5/jppres16.145_5.1.15.pdf |
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