Design, Synthesis, Bioactivity Evaluation, Crystal Structures, and In Silico Studies of New α-Amino Amide Derivatives as Potential Histone Deacetylase 6 Inhibitors

Design, Synthesis, Bioactivity Evaluation, Crystal Structures, and In Silico Studies of New α-Amino Amide Derivatives as Potential Histone Deacetylase 6 Inhibitors

Hydroxamate, as a zinc-binding group (ZBG), prevails in the design of histone deacetylase 6(HDAC6) inhibitors due to its remarkable zinc-chelating capability. However, hydroxamate-associated genotoxicity and mutagenicity have limited the widespread application of corresponding HDAC6 inhibitors in th...

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Bibliographic Details
Main Authors: Yangrong Xu, Hangjun Tang, Yijie Xu, Jialin Guo, Xu Zhao, Qingguo Meng, Junhai Xiao
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
HDAC6 inhibitors
non-hydroxamate
α-amino amide
synthesis
bioactivity evaluation
crystal structure
Online Access:https://www.mdpi.com/1420-3049/27/10/3335

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