Stochastic loss of silencing of the imprinted Ndn/NDN allele, in a mouse model and humans with prader-willi syndrome, has functional consequences.

Stochastic loss of silencing of the imprinted Ndn/NDN allele, in a mouse model and humans with prader-willi syndrome, has functional consequences.

Genomic imprinting is a process that causes genes to be expressed from one allele only according to parental origin, the other allele being silent. Diseases can arise when the normally active alleles are not expressed. In this context, low level of expression of the normally silent alleles has been...

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Detalles Bibliográficos
Main Authors: Anne Rieusset, Fabienne Schaller, Unga Unmehopa, Valery Matarazzo, Françoise Watrin, Matthias Linke, Beatrice Georges, Jocelyn Bischof, Femke Dijkstra, Monique Bloemsma, Severine Corby, François J Michel, Rachel Wevrick, Ulrich Zechner, Dick Swaab, Keith Dudley, Laurent Bezin, Françoise Muscatelli
Formato: Artigo
Idioma:English
Publicado: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Acceso en liña:http://europepmc.org/articles/PMC3764186?pdf=render

Internet

http://europepmc.org/articles/PMC3764186?pdf=render

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