The immune-dependence of chemotherapy in experimental schistosomiasis
Experimental evidence indicates that immune effector mechanisms can enhance the activity of schistosomicidal drugs. Praziquantel, oxamniquine, hycanthone and antimony were less effective against Schistosoma mansoni infections in mice immunosuppressed by T cell-deprivation, than against comparable in...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
1989-01-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761989000500004 |
| _version_ | 1797703214563328000 |
|---|---|
| author | M. J. Doenhoff |
| author_facet | M. J. Doenhoff |
| author_sort | M. J. Doenhoff |
| collection | DOAJ |
| description | Experimental evidence indicates that immune effector mechanisms can enhance the activity of schistosomicidal drugs. Praziquantel, oxamniquine, hycanthone and antimony were less effective against Schistosoma mansoni infections in mice immunosuppressed by T cell-deprivation, than against comparable infection in normal mice. The schistosomicidal activities of praziquantel, oxamniquine and antimony have been experimentally enhanced by the synergistic action of immune sera. In passive serum transfer experiments a s. mansoni antigen of Mr 27 kD with non-specific esterase activity was identified as a potentially sensitive target for the antibodies that interact with praziquantel. Indirect immunofluorescence indicated that this antigen was exposed on the worm surface as a result of praziquantel treatment. |
| first_indexed | 2024-03-12T05:01:20Z |
| format | Article |
| id | doaj.art-f2c3ea5af70d4608860a22f060ae8f6e |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:01:20Z |
| publishDate | 1989-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-f2c3ea5af70d4608860a22f060ae8f6e2023-09-03T09:11:46ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601989-01-0184313710.1590/S0074-02761989000500004The immune-dependence of chemotherapy in experimental schistosomiasisM. J. DoenhoffExperimental evidence indicates that immune effector mechanisms can enhance the activity of schistosomicidal drugs. Praziquantel, oxamniquine, hycanthone and antimony were less effective against Schistosoma mansoni infections in mice immunosuppressed by T cell-deprivation, than against comparable infection in normal mice. The schistosomicidal activities of praziquantel, oxamniquine and antimony have been experimentally enhanced by the synergistic action of immune sera. In passive serum transfer experiments a s. mansoni antigen of Mr 27 kD with non-specific esterase activity was identified as a potentially sensitive target for the antibodies that interact with praziquantel. Indirect immunofluorescence indicated that this antigen was exposed on the worm surface as a result of praziquantel treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761989000500004 |
| spellingShingle | M. J. Doenhoff The immune-dependence of chemotherapy in experimental schistosomiasis Memorias do Instituto Oswaldo Cruz |
| title | The immune-dependence of chemotherapy in experimental schistosomiasis |
| title_full | The immune-dependence of chemotherapy in experimental schistosomiasis |
| title_fullStr | The immune-dependence of chemotherapy in experimental schistosomiasis |
| title_full_unstemmed | The immune-dependence of chemotherapy in experimental schistosomiasis |
| title_short | The immune-dependence of chemotherapy in experimental schistosomiasis |
| title_sort | immune dependence of chemotherapy in experimental schistosomiasis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761989000500004 |
| work_keys_str_mv | AT mjdoenhoff theimmunedependenceofchemotherapyinexperimentalschistosomiasis AT mjdoenhoff immunedependenceofchemotherapyinexperimentalschistosomiasis |