Activation of Akt–mTORC1 signalling reverts cancer‐dependent muscle wasting

Activation of Akt–mTORC1 signalling reverts cancer‐dependent muscle wasting

Abstract Background Cancer‐related muscle wasting occurs in most cancer patients. An important regulator of adult muscle mass and function is the Akt–mTORC1 pathway. While Akt–mTORC1 signalling is important for adult muscle homeostasis, it is also a major target of numerous cancer treatments. Which...

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Bibliographic Details
Main Authors: Alessia Geremia, Roberta Sartori, Martina Baraldo, Leonardo Nogara, Valeria Balmaceda, Georgia Ana Dumitras, Stefano Ciciliot, Marco Scalabrin, Hendrik Nolte, Bert Blaauw
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Cancer cachexia
mTOR
Raptor
Akt
Muscle growth
Skeletal muscle force
Online Access:https://doi.org/10.1002/jcsm.12854

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