Axl promotes intracranial aneurysm rupture by regulating macrophage polarization toward M1 via STAT1/HIF-1α

Axl promotes intracranial aneurysm rupture by regulating macrophage polarization toward M1 via STAT1/HIF-1α

BackgroundMacrophage infiltration and polarization are crucial for the pathogenesis of intracranial aneurysm (IA) rupture. Axl, a receptor tyrosine kinase, is involved in inflammation and efferocytosis in multiple organs. Upregulated soluble Axl in cerebrospinal fluid (CSF) and plasma is correlated...

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Bibliographic Details
Main Authors: Yongquan Han, Gaozhi Li, Zeyu Zhang, Xiaohua Zhang, Bing Zhao, Hua Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
intracranial aneurysm
rupture
Axl
macrophage polarization
STAT1
HIF-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1158758/full

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