Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after systemic administration of Amoxicillin plus Metronidazole as an adjunct to non-surgical periodontal therapy: A Systematic Review and meta-analysis.
Objective: To evaluate the variations in the detection of Porphyromonas gingivalis and/or Aggregatibacter actinomycetemcomitans before and after systemic administration of amoxicillin plus metronidazole in association with non-surgical periodontal therapy.Background: The adjunctive use of antibiotic...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-08-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01277/full |
| _version_ | 1828313135919923200 |
|---|---|
| author | Aleksandar Dakic Adrien BOILLOT Adrien BOILLOT Cyrille Colliot Maria-Clotilde Carra Maria-Clotilde Carra Sebastien Czernichow Sebastien Czernichow Philippe Bouchard Philippe Bouchard |
| author_facet | Aleksandar Dakic Adrien BOILLOT Adrien BOILLOT Cyrille Colliot Maria-Clotilde Carra Maria-Clotilde Carra Sebastien Czernichow Sebastien Czernichow Philippe Bouchard Philippe Bouchard |
| author_sort | Aleksandar Dakic |
| collection | DOAJ |
| description | Objective: To evaluate the variations in the detection of Porphyromonas gingivalis and/or Aggregatibacter actinomycetemcomitans before and after systemic administration of amoxicillin plus metronidazole in association with non-surgical periodontal therapy.Background: The adjunctive use of antibiotics has been advocated to improve the clinical outcomes of non-surgical periodontal therapy. However, no systematic review has investigated the microbiological benefit of this combination. Material and Methods: An electronic search was conducted up to December 2015. Randomized clinical trials comparing the number of patients testing positive for Porphyromonas gingivalis and/or Aggregatibacter actinomycetemcomitans before and after non-surgical periodontal therapy with (test group) or without (control group) amoxicillin plus metronidazole were included. The difference between groups in the variation of positive patients was calculated using the inverse variance method with a random effects model.Results: The frequency of patients positive for Aggregatibacter actinomycetemcomitans was decreased by 30 % (p=0.002) and by 25 % (p=0.01) in the test group compared to the control group at 3-month and 6-month follow-up, respectively. Similar findings were observed when considering the frequency of patients positive for Porphyromonas gingivalis, with a reduction by 28 % (p<0.0001), 32% (p<0.0001) and 34% (p=0.03) in the test group compared to the control group at 3-month, 6-month and 12-month follow-up, respectively. Conclusion: The systemic administration of amoxicillin plus metronidazole as an adjunct to non-surgical periodontal therapy significantly decreased the number of patients positive for Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans compared with periodontal therapy alone or with a placebo. |
| first_indexed | 2024-04-13T16:26:20Z |
| format | Article |
| id | doaj.art-f2c929539d4943c0970c226302f838b9 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T16:26:20Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-f2c929539d4943c0970c226302f838b92022-12-22T02:39:44ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-08-01710.3389/fmicb.2016.01277206137Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after systemic administration of Amoxicillin plus Metronidazole as an adjunct to non-surgical periodontal therapy: A Systematic Review and meta-analysis.Aleksandar Dakic0Adrien BOILLOT1Adrien BOILLOT2Cyrille Colliot3Maria-Clotilde Carra4Maria-Clotilde Carra5Sebastien Czernichow6Sebastien Czernichow7Philippe Bouchard8Philippe Bouchard9Rothschild Hospital, AP-HP; U.F.R. of Odontology, Paris Diderot UniversityRothschild Hospital, AP-HP; U.F.R. of Odontology, Paris Diderot UniversityUMS 011, Population-based Epidemiologic Cohorts Unit, INSERMRothschild Hospital, AP-HP; U.F.R. of Odontology, Paris Diderot UniversityRothschild Hospital, AP-HP; U.F.R. of Odontology, Paris Diderot UniversityUMS 011, Population-based Epidemiologic Cohorts Unit, INSERMUMS 011, Population-based Epidemiologic Cohorts Unit, INSERMDepartment of Nutrition, Hôpital Européen Georges Pompidou, AP-HP, Paris Descartes UniversityRothschild Hospital, AP-HP; U.F.R. of Odontology, Paris Diderot UniversityU.F.R. of Odontology, Paris Descartes University, Montrouge, FranceObjective: To evaluate the variations in the detection of Porphyromonas gingivalis and/or Aggregatibacter actinomycetemcomitans before and after systemic administration of amoxicillin plus metronidazole in association with non-surgical periodontal therapy.Background: The adjunctive use of antibiotics has been advocated to improve the clinical outcomes of non-surgical periodontal therapy. However, no systematic review has investigated the microbiological benefit of this combination. Material and Methods: An electronic search was conducted up to December 2015. Randomized clinical trials comparing the number of patients testing positive for Porphyromonas gingivalis and/or Aggregatibacter actinomycetemcomitans before and after non-surgical periodontal therapy with (test group) or without (control group) amoxicillin plus metronidazole were included. The difference between groups in the variation of positive patients was calculated using the inverse variance method with a random effects model.Results: The frequency of patients positive for Aggregatibacter actinomycetemcomitans was decreased by 30 % (p=0.002) and by 25 % (p=0.01) in the test group compared to the control group at 3-month and 6-month follow-up, respectively. Similar findings were observed when considering the frequency of patients positive for Porphyromonas gingivalis, with a reduction by 28 % (p<0.0001), 32% (p<0.0001) and 34% (p=0.03) in the test group compared to the control group at 3-month, 6-month and 12-month follow-up, respectively. Conclusion: The systemic administration of amoxicillin plus metronidazole as an adjunct to non-surgical periodontal therapy significantly decreased the number of patients positive for Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans compared with periodontal therapy alone or with a placebo.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01277/fullAmoxicillinMetronidazolePorphyromonas gingivalisMeta-analysisAggregatibacter actinomycetemcomitansPeriodontitis/therapy |
| spellingShingle | Aleksandar Dakic Adrien BOILLOT Adrien BOILLOT Cyrille Colliot Maria-Clotilde Carra Maria-Clotilde Carra Sebastien Czernichow Sebastien Czernichow Philippe Bouchard Philippe Bouchard Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after systemic administration of Amoxicillin plus Metronidazole as an adjunct to non-surgical periodontal therapy: A Systematic Review and meta-analysis. Frontiers in Microbiology Amoxicillin Metronidazole Porphyromonas gingivalis Meta-analysis Aggregatibacter actinomycetemcomitans Periodontitis/therapy |
| title | Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after systemic administration of Amoxicillin plus Metronidazole as an adjunct to non-surgical periodontal therapy: A Systematic Review and meta-analysis. |
| title_full | Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after systemic administration of Amoxicillin plus Metronidazole as an adjunct to non-surgical periodontal therapy: A Systematic Review and meta-analysis. |
| title_fullStr | Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after systemic administration of Amoxicillin plus Metronidazole as an adjunct to non-surgical periodontal therapy: A Systematic Review and meta-analysis. |
| title_full_unstemmed | Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after systemic administration of Amoxicillin plus Metronidazole as an adjunct to non-surgical periodontal therapy: A Systematic Review and meta-analysis. |
| title_short | Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after systemic administration of Amoxicillin plus Metronidazole as an adjunct to non-surgical periodontal therapy: A Systematic Review and meta-analysis. |
| title_sort | detection of porphyromonas gingivalis and aggregatibacter actinomycetemcomitans after systemic administration of amoxicillin plus metronidazole as an adjunct to non surgical periodontal therapy a systematic review and meta analysis |
| topic | Amoxicillin Metronidazole Porphyromonas gingivalis Meta-analysis Aggregatibacter actinomycetemcomitans Periodontitis/therapy |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01277/full |
| work_keys_str_mv | AT aleksandardakic detectionofporphyromonasgingivalisandaggregatibacteractinomycetemcomitansaftersystemicadministrationofamoxicillinplusmetronidazoleasanadjuncttononsurgicalperiodontaltherapyasystematicreviewandmetaanalysis AT adrienboillot detectionofporphyromonasgingivalisandaggregatibacteractinomycetemcomitansaftersystemicadministrationofamoxicillinplusmetronidazoleasanadjuncttononsurgicalperiodontaltherapyasystematicreviewandmetaanalysis AT adrienboillot detectionofporphyromonasgingivalisandaggregatibacteractinomycetemcomitansaftersystemicadministrationofamoxicillinplusmetronidazoleasanadjuncttononsurgicalperiodontaltherapyasystematicreviewandmetaanalysis AT cyrillecolliot detectionofporphyromonasgingivalisandaggregatibacteractinomycetemcomitansaftersystemicadministrationofamoxicillinplusmetronidazoleasanadjuncttononsurgicalperiodontaltherapyasystematicreviewandmetaanalysis AT mariaclotildecarra detectionofporphyromonasgingivalisandaggregatibacteractinomycetemcomitansaftersystemicadministrationofamoxicillinplusmetronidazoleasanadjuncttononsurgicalperiodontaltherapyasystematicreviewandmetaanalysis AT mariaclotildecarra detectionofporphyromonasgingivalisandaggregatibacteractinomycetemcomitansaftersystemicadministrationofamoxicillinplusmetronidazoleasanadjuncttononsurgicalperiodontaltherapyasystematicreviewandmetaanalysis AT sebastienczernichow detectionofporphyromonasgingivalisandaggregatibacteractinomycetemcomitansaftersystemicadministrationofamoxicillinplusmetronidazoleasanadjuncttononsurgicalperiodontaltherapyasystematicreviewandmetaanalysis AT sebastienczernichow detectionofporphyromonasgingivalisandaggregatibacteractinomycetemcomitansaftersystemicadministrationofamoxicillinplusmetronidazoleasanadjuncttononsurgicalperiodontaltherapyasystematicreviewandmetaanalysis AT philippebouchard detectionofporphyromonasgingivalisandaggregatibacteractinomycetemcomitansaftersystemicadministrationofamoxicillinplusmetronidazoleasanadjuncttononsurgicalperiodontaltherapyasystematicreviewandmetaanalysis AT philippebouchard detectionofporphyromonasgingivalisandaggregatibacteractinomycetemcomitansaftersystemicadministrationofamoxicillinplusmetronidazoleasanadjuncttononsurgicalperiodontaltherapyasystematicreviewandmetaanalysis |