Recent advances in Fe-based bioresorbable stents: Materials design and biosafety
Fe-based materials have received more and more interests in recent years as candidates to fabricate bioresorbable stents due to their appropriate mechanical properties and biocompatibility. However, the low degradation rate of Fe is a serious limitation for such application. To overcome this critica...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2024-01-01
|
| Series: | Bioactive Materials |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23002372 |
| _version_ | 1797736244276363264 |
|---|---|
| author | Yang Zhang Charles Roux Aymeric Rouchaud Anne Meddahi-Pellé Virginie Gueguen Claire Mangeney Fan Sun Graciela Pavon-Djavid Yun Luo |
| author_facet | Yang Zhang Charles Roux Aymeric Rouchaud Anne Meddahi-Pellé Virginie Gueguen Claire Mangeney Fan Sun Graciela Pavon-Djavid Yun Luo |
| author_sort | Yang Zhang |
| collection | DOAJ |
| description | Fe-based materials have received more and more interests in recent years as candidates to fabricate bioresorbable stents due to their appropriate mechanical properties and biocompatibility. However, the low degradation rate of Fe is a serious limitation for such application. To overcome this critical issue, many efforts have been devoted to accelerate the corrosion rate of Fe-based stents, through the structural and surface modification of Fe matrix. As stents are implantable devices, the released corrosion products (Fe2+ ions) in vessels may alter the metabolism, by generating reactive oxygen species (ROS), which might in turn impact the biosafety of Fe-based stents. These considerations emphasize the importance of combining knowledge in both materials and biological science for the development of efficient and safe Fe-based stents, although there are still only limited numbers of reviews regarding this interdisciplinary field. This review aims to provide a concise overview of the main strategies developed so far to design Fe-based stents with accelerated degradation, highlighting the fundamental mechanisms of corrosion and the methods to study them as well as the reported approaches to accelerate the corrosion rates. These approaches will be divided into four main sections, focusing on (i) increased active surface areas, (ii) tailored microstructures, (iii) creation of galvanic reactions (by alloying, ion implantation or surface coating of noble metals) and (iv) decreased local pH induced by degradable surface organic layers. Recent advances in the evaluation of the in vitro biocompatibility of the final materials and ongoing in vivo tests are also provided. |
| first_indexed | 2024-03-12T13:10:50Z |
| format | Article |
| id | doaj.art-f2c92e1b20834791880b4195e46ed29f |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-03-12T13:10:50Z |
| publishDate | 2024-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-f2c92e1b20834791880b4195e46ed29f2023-08-28T04:23:05ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2024-01-0131333354Recent advances in Fe-based bioresorbable stents: Materials design and biosafetyYang Zhang0Charles Roux1Aymeric Rouchaud2Anne Meddahi-Pellé3Virginie Gueguen4Claire Mangeney5Fan Sun6Graciela Pavon-Djavid7Yun Luo8Université Paris Cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, F-75006, Paris, France; Université Sorbonne Paris Nord, INSERM U1148, Laboratory for Vascular Translational Science, Cardiovascular Bioengineering, 99 Av. Jean-Baptiste Clément, 93430, Villetaneuse, FranceUniv. Limoges, CNRS, XLIM, UMR 7252, Limoges, FranceUniv. Limoges, CNRS, XLIM, UMR 7252, Limoges, FranceUniversité Sorbonne Paris Nord, INSERM U1148, Laboratory for Vascular Translational Science, Cardiovascular Bioengineering, 99 Av. Jean-Baptiste Clément, 93430, Villetaneuse, FranceUniversité Sorbonne Paris Nord, INSERM U1148, Laboratory for Vascular Translational Science, Cardiovascular Bioengineering, 99 Av. Jean-Baptiste Clément, 93430, Villetaneuse, FranceUniversité Paris Cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, F-75006, Paris, FrancePSL Université, Chimie Paris Tech, IRCP, CNRS UMR 8247, 11, Rue Pierre et Marie Curie, 75005, Paris, France; Corresponding author.Université Sorbonne Paris Nord, INSERM U1148, Laboratory for Vascular Translational Science, Cardiovascular Bioengineering, 99 Av. Jean-Baptiste Clément, 93430, Villetaneuse, France; Corresponding author.Université Paris Cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, F-75006, Paris, France; Corresponding author.Fe-based materials have received more and more interests in recent years as candidates to fabricate bioresorbable stents due to their appropriate mechanical properties and biocompatibility. However, the low degradation rate of Fe is a serious limitation for such application. To overcome this critical issue, many efforts have been devoted to accelerate the corrosion rate of Fe-based stents, through the structural and surface modification of Fe matrix. As stents are implantable devices, the released corrosion products (Fe2+ ions) in vessels may alter the metabolism, by generating reactive oxygen species (ROS), which might in turn impact the biosafety of Fe-based stents. These considerations emphasize the importance of combining knowledge in both materials and biological science for the development of efficient and safe Fe-based stents, although there are still only limited numbers of reviews regarding this interdisciplinary field. This review aims to provide a concise overview of the main strategies developed so far to design Fe-based stents with accelerated degradation, highlighting the fundamental mechanisms of corrosion and the methods to study them as well as the reported approaches to accelerate the corrosion rates. These approaches will be divided into four main sections, focusing on (i) increased active surface areas, (ii) tailored microstructures, (iii) creation of galvanic reactions (by alloying, ion implantation or surface coating of noble metals) and (iv) decreased local pH induced by degradable surface organic layers. Recent advances in the evaluation of the in vitro biocompatibility of the final materials and ongoing in vivo tests are also provided.http://www.sciencedirect.com/science/article/pii/S2452199X23002372 |
| spellingShingle | Yang Zhang Charles Roux Aymeric Rouchaud Anne Meddahi-Pellé Virginie Gueguen Claire Mangeney Fan Sun Graciela Pavon-Djavid Yun Luo Recent advances in Fe-based bioresorbable stents: Materials design and biosafety Bioactive Materials |
| title | Recent advances in Fe-based bioresorbable stents: Materials design and biosafety |
| title_full | Recent advances in Fe-based bioresorbable stents: Materials design and biosafety |
| title_fullStr | Recent advances in Fe-based bioresorbable stents: Materials design and biosafety |
| title_full_unstemmed | Recent advances in Fe-based bioresorbable stents: Materials design and biosafety |
| title_short | Recent advances in Fe-based bioresorbable stents: Materials design and biosafety |
| title_sort | recent advances in fe based bioresorbable stents materials design and biosafety |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23002372 |
| work_keys_str_mv | AT yangzhang recentadvancesinfebasedbioresorbablestentsmaterialsdesignandbiosafety AT charlesroux recentadvancesinfebasedbioresorbablestentsmaterialsdesignandbiosafety AT aymericrouchaud recentadvancesinfebasedbioresorbablestentsmaterialsdesignandbiosafety AT annemeddahipelle recentadvancesinfebasedbioresorbablestentsmaterialsdesignandbiosafety AT virginiegueguen recentadvancesinfebasedbioresorbablestentsmaterialsdesignandbiosafety AT clairemangeney recentadvancesinfebasedbioresorbablestentsmaterialsdesignandbiosafety AT fansun recentadvancesinfebasedbioresorbablestentsmaterialsdesignandbiosafety AT gracielapavondjavid recentadvancesinfebasedbioresorbablestentsmaterialsdesignandbiosafety AT yunluo recentadvancesinfebasedbioresorbablestentsmaterialsdesignandbiosafety |