Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells
Tumors are composed by a heterogeneous population of cells. Among them, a sub-population of cells, termed cancer stem cells, exhibit stemness features, such as self-renewal capabilities, disposition to differentiate to a more proliferative state, and chemotherapy resistance, processes that are all m...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/8/1332 |
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| author | Isaac Jardin Jose J. Lopez Jose Sanchez-Collado Luis J. Gomez Gines M. Salido Juan A. Rosado |
| author_facet | Isaac Jardin Jose J. Lopez Jose Sanchez-Collado Luis J. Gomez Gines M. Salido Juan A. Rosado |
| author_sort | Isaac Jardin |
| collection | DOAJ |
| description | Tumors are composed by a heterogeneous population of cells. Among them, a sub-population of cells, termed cancer stem cells, exhibit stemness features, such as self-renewal capabilities, disposition to differentiate to a more proliferative state, and chemotherapy resistance, processes that are all mediated by Ca<sup>2+</sup>. Ca<sup>2+</sup> homeostasis is vital for several physiological processes, and alterations in the patterns of expressions of the proteins and molecules that modulate it have recently become a cancer hallmark. Store-operated Ca<sup>2+</sup> entry is a major mechanism for Ca<sup>2+</sup> entry from the extracellular medium in non-excitable cells that leads to increases in the cytosolic Ca<sup>2+</sup> concentration required for several processes, including cancer stem cell properties. Here, we focus on the participation of STIM, Orai, and TRPC proteins, the store-operated Ca<sup>2+</sup> entry key components, in cancer stem cell biology and tumorigenesis. |
| first_indexed | 2024-03-09T11:01:43Z |
| format | Article |
| id | doaj.art-f2c9317313f44cafb31587a129282674 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T11:01:43Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f2c9317313f44cafb31587a1292826742023-12-01T01:14:37ZengMDPI AGCells2073-44092022-04-01118133210.3390/cells11081332Store-Operated Calcium Entry and Its Implications in Cancer Stem CellsIsaac Jardin0Jose J. Lopez1Jose Sanchez-Collado2Luis J. Gomez3Gines M. Salido4Juan A. Rosado5Cellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainCellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainCellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainCellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainCellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainCellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainTumors are composed by a heterogeneous population of cells. Among them, a sub-population of cells, termed cancer stem cells, exhibit stemness features, such as self-renewal capabilities, disposition to differentiate to a more proliferative state, and chemotherapy resistance, processes that are all mediated by Ca<sup>2+</sup>. Ca<sup>2+</sup> homeostasis is vital for several physiological processes, and alterations in the patterns of expressions of the proteins and molecules that modulate it have recently become a cancer hallmark. Store-operated Ca<sup>2+</sup> entry is a major mechanism for Ca<sup>2+</sup> entry from the extracellular medium in non-excitable cells that leads to increases in the cytosolic Ca<sup>2+</sup> concentration required for several processes, including cancer stem cell properties. Here, we focus on the participation of STIM, Orai, and TRPC proteins, the store-operated Ca<sup>2+</sup> entry key components, in cancer stem cell biology and tumorigenesis.https://www.mdpi.com/2073-4409/11/8/1332store-operated calcium entryOrai1cancer stem cells |
| spellingShingle | Isaac Jardin Jose J. Lopez Jose Sanchez-Collado Luis J. Gomez Gines M. Salido Juan A. Rosado Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells Cells store-operated calcium entry Orai1 cancer stem cells |
| title | Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells |
| title_full | Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells |
| title_fullStr | Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells |
| title_full_unstemmed | Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells |
| title_short | Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells |
| title_sort | store operated calcium entry and its implications in cancer stem cells |
| topic | store-operated calcium entry Orai1 cancer stem cells |
| url | https://www.mdpi.com/2073-4409/11/8/1332 |
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