Hypertriglyceridemia–induced acute pancreatitis: A systematic review of the literature
Objective: To summarize the current evidence about the hypertriglyceridemia–induced acute pancreatitis (HAP). Methods: Systematic review of the English language literature was conducted using PubMed/ Medline database from its inception until August 2016. As a searching methodology, we have used a co...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Acute Disease |
| Subjects: | |
| Online Access: | http://www.jadweb.org/article.asp?issn=2221-6189;year=2017;volume=6;issue=1;spage=1;epage=5;aulast=Negoi |
| _version_ | 1828738006278733824 |
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| author | Ionut Negoi Sorin Paun Massimo Sartelli Fausto Catena Luca Ansaloni Ruxandra Irina Negoi Mircea Beuran |
| author_facet | Ionut Negoi Sorin Paun Massimo Sartelli Fausto Catena Luca Ansaloni Ruxandra Irina Negoi Mircea Beuran |
| author_sort | Ionut Negoi |
| collection | DOAJ |
| description | Objective: To summarize the current evidence about the hypertriglyceridemia–induced acute pancreatitis (HAP).
Methods: Systematic review of the English language literature was conducted using PubMed/ Medline database from its inception until August 2016. As a searching methodology, we have used a combination of ‘acute pancreatitis’ and ‘hypertriglyceridemia’ as keywords into the title.
>Results: The diagnosis of HAP should be based on two out of the three criteria recommended by the international guidelines: characteristic clinical picture, serum pancreatic enzymes, and appropriate imagistics. The diagnosis of HAP should be distinguished between mild hypertriglyceridemia (> 150 mg/dL), which accompanies around one-third of all-causes acute pancreatitis, and severe hypertriglyceridemia (> 1 000 mg/dL) which generates acute pancreatitis. There is mixed evidence regarding a worse prognosis for patients with HAP, and a clear conclusion cannot be drawn. Similar to all the other etiologies, in HAP the initial treatment efforts should be nonspecific and addressed to acute pancreatitis, while pharmacologic and mechanical techniques should be added to lower the serum triglycerides as soon as possible.
>Conclusions: We may conclude that HAP should be managed to respect all the general principles, also adding all the available resources to lower the serum triglycerides value, as early as possible in the acute setting and on long-term to prevent recurrences. |
| first_indexed | 2024-04-12T23:55:17Z |
| format | Article |
| id | doaj.art-f2c974b54cbd407eaadce6d11ac95623 |
| institution | Directory Open Access Journal |
| issn | 2221-6189 2589-5516 |
| language | English |
| last_indexed | 2024-04-12T23:55:17Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Acute Disease |
| spelling | doaj.art-f2c974b54cbd407eaadce6d11ac956232022-12-22T03:11:33ZengWolters Kluwer Medknow PublicationsJournal of Acute Disease2221-61892589-55162017-01-01611510.12980/jad.6.2017JADWEB-2016-0058Hypertriglyceridemia–induced acute pancreatitis: A systematic review of the literatureIonut NegoiSorin PaunMassimo SartelliFausto CatenaLuca AnsaloniRuxandra Irina NegoiMircea BeuranObjective: To summarize the current evidence about the hypertriglyceridemia–induced acute pancreatitis (HAP). Methods: Systematic review of the English language literature was conducted using PubMed/ Medline database from its inception until August 2016. As a searching methodology, we have used a combination of ‘acute pancreatitis’ and ‘hypertriglyceridemia’ as keywords into the title. >Results: The diagnosis of HAP should be based on two out of the three criteria recommended by the international guidelines: characteristic clinical picture, serum pancreatic enzymes, and appropriate imagistics. The diagnosis of HAP should be distinguished between mild hypertriglyceridemia (> 150 mg/dL), which accompanies around one-third of all-causes acute pancreatitis, and severe hypertriglyceridemia (> 1 000 mg/dL) which generates acute pancreatitis. There is mixed evidence regarding a worse prognosis for patients with HAP, and a clear conclusion cannot be drawn. Similar to all the other etiologies, in HAP the initial treatment efforts should be nonspecific and addressed to acute pancreatitis, while pharmacologic and mechanical techniques should be added to lower the serum triglycerides as soon as possible. >Conclusions: We may conclude that HAP should be managed to respect all the general principles, also adding all the available resources to lower the serum triglycerides value, as early as possible in the acute setting and on long-term to prevent recurrences.http://www.jadweb.org/article.asp?issn=2221-6189;year=2017;volume=6;issue=1;spage=1;epage=5;aulast=NegoiHypertriglyceridemia-inducedAcute pancreatitisSystematic reviewEtiology |
| spellingShingle | Ionut Negoi Sorin Paun Massimo Sartelli Fausto Catena Luca Ansaloni Ruxandra Irina Negoi Mircea Beuran Hypertriglyceridemia–induced acute pancreatitis: A systematic review of the literature Journal of Acute Disease Hypertriglyceridemia-induced Acute pancreatitis Systematic review Etiology |
| title | Hypertriglyceridemia–induced acute pancreatitis: A systematic review of the literature |
| title_full | Hypertriglyceridemia–induced acute pancreatitis: A systematic review of the literature |
| title_fullStr | Hypertriglyceridemia–induced acute pancreatitis: A systematic review of the literature |
| title_full_unstemmed | Hypertriglyceridemia–induced acute pancreatitis: A systematic review of the literature |
| title_short | Hypertriglyceridemia–induced acute pancreatitis: A systematic review of the literature |
| title_sort | hypertriglyceridemia induced acute pancreatitis a systematic review of the literature |
| topic | Hypertriglyceridemia-induced Acute pancreatitis Systematic review Etiology |
| url | http://www.jadweb.org/article.asp?issn=2221-6189;year=2017;volume=6;issue=1;spage=1;epage=5;aulast=Negoi |
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