Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility
ABSTRACT Objective: This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A - rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population. Methods: Polymerase chain reaction-rest...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Reumatologia
|
| Series: | Revista Brasileira de Reumatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000600483&lng=en&tlng=en |
| _version_ | 1818363134425956352 |
|---|---|
| author | Luisa Matos do Canto Ticiana Della Justina Farias Mayara Delagnelo Medeiros Cíntia Callegari Coêlho Aline Fernanda Rodrigues Sereia Lia Kubelka Fernandes de Carlos Back Filipe Martins de Mello Adriana Fontes Zimmermann Ivânio Alves Pereira Ilíada Rainha de Souza |
| author_facet | Luisa Matos do Canto Ticiana Della Justina Farias Mayara Delagnelo Medeiros Cíntia Callegari Coêlho Aline Fernanda Rodrigues Sereia Lia Kubelka Fernandes de Carlos Back Filipe Martins de Mello Adriana Fontes Zimmermann Ivânio Alves Pereira Ilíada Rainha de Souza |
| author_sort | Luisa Matos do Canto |
| collection | DOAJ |
| description | ABSTRACT Objective: This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A - rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy-Weinberg equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p ≤ 0.05. Results: The PD1.3A allele frequencies were 0.095 (SLE), 0.115 (RA) and 0.078 (controls). The genotypes of the control group were in HWE, while those of SLE and RA patients were not. However, we found no association between PD1.3 polymorphism and the SLE or RA susceptibility, nor clinical or epidemiological data. Conclusion: There was no significant association between PD1.3 polymorphism and SLE or RA susceptibility in this Southern Brazilian population. |
| first_indexed | 2024-12-13T21:43:39Z |
| format | Article |
| id | doaj.art-f2c9f8ab55e143308b546bb4212e4ece |
| institution | Directory Open Access Journal |
| issn | 1809-4570 |
| language | English |
| last_indexed | 2024-12-13T21:43:39Z |
| publisher | Sociedade Brasileira de Reumatologia |
| record_format | Article |
| series | Revista Brasileira de Reumatologia |
| spelling | doaj.art-f2c9f8ab55e143308b546bb4212e4ece2022-12-21T23:30:29ZengSociedade Brasileira de ReumatologiaRevista Brasileira de Reumatologia1809-457056648348910.1016/j.rbre.2015.07.008S0482-50042016000600483Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibilityLuisa Matos do CantoTiciana Della Justina FariasMayara Delagnelo MedeirosCíntia Callegari CoêlhoAline Fernanda Rodrigues SereiaLia Kubelka Fernandes de Carlos BackFilipe Martins de MelloAdriana Fontes ZimmermannIvânio Alves PereiraIlíada Rainha de SouzaABSTRACT Objective: This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A - rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy-Weinberg equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p ≤ 0.05. Results: The PD1.3A allele frequencies were 0.095 (SLE), 0.115 (RA) and 0.078 (controls). The genotypes of the control group were in HWE, while those of SLE and RA patients were not. However, we found no association between PD1.3 polymorphism and the SLE or RA susceptibility, nor clinical or epidemiological data. Conclusion: There was no significant association between PD1.3 polymorphism and SLE or RA susceptibility in this Southern Brazilian population.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000600483&lng=en&tlng=enArtrite reumatoideLúpus eritematoso sistêmicoAutoimunidadeGene PDCD1Polimorfismo PD1.3 |
| spellingShingle | Luisa Matos do Canto Ticiana Della Justina Farias Mayara Delagnelo Medeiros Cíntia Callegari Coêlho Aline Fernanda Rodrigues Sereia Lia Kubelka Fernandes de Carlos Back Filipe Martins de Mello Adriana Fontes Zimmermann Ivânio Alves Pereira Ilíada Rainha de Souza Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility Revista Brasileira de Reumatologia Artrite reumatoide Lúpus eritematoso sistêmico Autoimunidade Gene PDCD1 Polimorfismo PD1.3 |
| title | Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility |
| title_full | Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility |
| title_fullStr | Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility |
| title_full_unstemmed | Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility |
| title_short | Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility |
| title_sort | association of pdcd1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility |
| topic | Artrite reumatoide Lúpus eritematoso sistêmico Autoimunidade Gene PDCD1 Polimorfismo PD1.3 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000600483&lng=en&tlng=en |
| work_keys_str_mv | AT luisamatosdocanto associationofpdcd1polymorphismtosystemiclupuserythematosusandrheumatoidarthritissusceptibility AT ticianadellajustinafarias associationofpdcd1polymorphismtosystemiclupuserythematosusandrheumatoidarthritissusceptibility AT mayaradelagnelomedeiros associationofpdcd1polymorphismtosystemiclupuserythematosusandrheumatoidarthritissusceptibility AT cintiacallegaricoelho associationofpdcd1polymorphismtosystemiclupuserythematosusandrheumatoidarthritissusceptibility AT alinefernandarodriguessereia associationofpdcd1polymorphismtosystemiclupuserythematosusandrheumatoidarthritissusceptibility AT liakubelkafernandesdecarlosback associationofpdcd1polymorphismtosystemiclupuserythematosusandrheumatoidarthritissusceptibility AT filipemartinsdemello associationofpdcd1polymorphismtosystemiclupuserythematosusandrheumatoidarthritissusceptibility AT adrianafonteszimmermann associationofpdcd1polymorphismtosystemiclupuserythematosusandrheumatoidarthritissusceptibility AT ivanioalvespereira associationofpdcd1polymorphismtosystemiclupuserythematosusandrheumatoidarthritissusceptibility AT iliadarainhadesouza associationofpdcd1polymorphismtosystemiclupuserythematosusandrheumatoidarthritissusceptibility |