Microbial perspective on the skin–gut axis and atopic dermatitis
Atopic dermatitis (AD) is a relapsing inflammatory skin condition that has become a global health issue with complex etiology and mounting prevalence. The association of AD with skin and gut microbiota has been revealed by virtue of the continuous development of sequencing technology and genomics an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-04-01
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| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2022-0782 |
| _version_ | 1827283652222910464 |
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| author | Qu Bo Zhang Xue-er Feng Haoyue Yan Bonan Bai Yingchun Liu Shanlin He Yuhua |
| author_facet | Qu Bo Zhang Xue-er Feng Haoyue Yan Bonan Bai Yingchun Liu Shanlin He Yuhua |
| author_sort | Qu Bo |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a relapsing inflammatory skin condition that has become a global health issue with complex etiology and mounting prevalence. The association of AD with skin and gut microbiota has been revealed by virtue of the continuous development of sequencing technology and genomics analysis. Also, the gut–brain–skin axis and its mutual crosstalk mechanisms have been gradually verified. Accordingly, the microbiota–skin–gut axis also plays an important role in allergic skin inflammation. Herein, we reviewed the relationship between the microbiota–skin–gut axis and AD, explored the underlying signaling molecules and potential pathways, and focused on the potential mechanisms of probiotics, antimicrobial peptides (AMPs), coagulase-negative staphylococci transplantation, fecal microbiota transplantation, AMPs, and addition of essential fatty acids in alleviating AD, with the aim to provide a new perspective for targeting microbiota in the treatment of allergic skin inflammation. |
| first_indexed | 2024-04-24T09:40:29Z |
| format | Article |
| id | doaj.art-f2caaf10f65f4d8cb59eec1ed55bffc6 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-24T09:40:29Z |
| publishDate | 2024-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-f2caaf10f65f4d8cb59eec1ed55bffc62024-04-15T07:41:02ZengDe GruyterOpen Life Sciences2391-54122024-04-0119181610.1515/biol-2022-0782Microbial perspective on the skin–gut axis and atopic dermatitisQu Bo0Zhang Xue-er1Feng Haoyue2Yan Bonan3Bai Yingchun4Liu Shanlin5He Yuhua6Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu, 610072, Sichuan Province, P.R. ChinaChengdu University of Traditional Chinese Medicine, No. 37 Shi-er-qiao Road, Chengdu, 610072, Sichuan Province, P.R. ChinaHospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu, 610072, Sichuan Province, P.R. ChinaChengdu University of Traditional Chinese Medicine, No. 37 Shi-er-qiao Road, Chengdu, 610072, Sichuan Province, P.R. ChinaHospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu, 610072, Sichuan Province, P.R. ChinaChengdu University of Traditional Chinese Medicine, No. 37 Shi-er-qiao Road, Chengdu, 610072, Sichuan Province, P.R. ChinaHospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu, 610072, Sichuan Province, P.R. ChinaAtopic dermatitis (AD) is a relapsing inflammatory skin condition that has become a global health issue with complex etiology and mounting prevalence. The association of AD with skin and gut microbiota has been revealed by virtue of the continuous development of sequencing technology and genomics analysis. Also, the gut–brain–skin axis and its mutual crosstalk mechanisms have been gradually verified. Accordingly, the microbiota–skin–gut axis also plays an important role in allergic skin inflammation. Herein, we reviewed the relationship between the microbiota–skin–gut axis and AD, explored the underlying signaling molecules and potential pathways, and focused on the potential mechanisms of probiotics, antimicrobial peptides (AMPs), coagulase-negative staphylococci transplantation, fecal microbiota transplantation, AMPs, and addition of essential fatty acids in alleviating AD, with the aim to provide a new perspective for targeting microbiota in the treatment of allergic skin inflammation.https://doi.org/10.1515/biol-2022-0782atopic dermatitismicrobiomegenomicsgutskin axisimmunology |
| spellingShingle | Qu Bo Zhang Xue-er Feng Haoyue Yan Bonan Bai Yingchun Liu Shanlin He Yuhua Microbial perspective on the skin–gut axis and atopic dermatitis Open Life Sciences atopic dermatitis microbiome genomics gut skin axis immunology |
| title | Microbial perspective on the skin–gut axis and atopic dermatitis |
| title_full | Microbial perspective on the skin–gut axis and atopic dermatitis |
| title_fullStr | Microbial perspective on the skin–gut axis and atopic dermatitis |
| title_full_unstemmed | Microbial perspective on the skin–gut axis and atopic dermatitis |
| title_short | Microbial perspective on the skin–gut axis and atopic dermatitis |
| title_sort | microbial perspective on the skin gut axis and atopic dermatitis |
| topic | atopic dermatitis microbiome genomics gut skin axis immunology |
| url | https://doi.org/10.1515/biol-2022-0782 |
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