Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles
Aim 2-HP-β-cyclodextrin-PLGA nanoparticle complexes were prepared to enhance the aqueous humour delivery of Triamcinolone acetonide.Materials & methods Drug-loaded 2-HP-β-CD/PLGA nanoparticle complexes prepared by adapting a quasi-emulsion solvent evaporation technique. In vitro drug release, in...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1683567 |
| _version_ | 1818140172801277952 |
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| author | Fan Li Yuqin Wen Yan Zhang Kangyu Zheng Junfeng Ban Qingchun Xie Yifeng Wen Qing Liu Fohua Chen Zhenjie Mo Lizhong Liu Yanzhong Chen Zhufen Lu |
| author_facet | Fan Li Yuqin Wen Yan Zhang Kangyu Zheng Junfeng Ban Qingchun Xie Yifeng Wen Qing Liu Fohua Chen Zhenjie Mo Lizhong Liu Yanzhong Chen Zhufen Lu |
| author_sort | Fan Li |
| collection | DOAJ |
| description | Aim 2-HP-β-cyclodextrin-PLGA nanoparticle complexes were prepared to enhance the aqueous humour delivery of Triamcinolone acetonide.Materials & methods Drug-loaded 2-HP-β-CD/PLGA nanoparticle complexes prepared by adapting a quasi-emulsion solvent evaporation technique. In vitro drug release, in vitro transcorneal permeation study, histopathological study and in vivo transcorneal penetration of PLGA nanoparticles and 2-HP-β-CD/PLGA nanoparticle complexes were evaluated. Results Particle size distributions of 2-HP-β-CD/PLGA nanoparticle complexes were 149.4 ± 3.7 nm and presented stable system. Corneal penetration studies revealed steady sustained drug release (First-order); 2-HP-β-CD/PLGA nanoparticle complexes increased ocular bioavailability by increasing dispersion in the tear film and improving drug release. Conclusion 2-HP-β-CD/PLGA nanoparticle complex formulation is a promising alternative to conventional eye drops. |
| first_indexed | 2024-12-11T10:39:46Z |
| format | Article |
| id | doaj.art-f2cac8d346854f75b0c904bf4889ba43 |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-12-11T10:39:46Z |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-f2cac8d346854f75b0c904bf4889ba432022-12-22T01:10:37ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2019-12-014714097410810.1080/21691401.2019.1683567Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehiclesFan Li0Yuqin Wen1Yan Zhang2Kangyu Zheng3Junfeng Ban4Qingchun Xie5Yifeng Wen6Qing Liu7Fohua Chen8Zhenjie Mo9Lizhong Liu10Yanzhong Chen11Zhufen Lu12Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaDepartment of Hospital Pharmacy, Ningbo 7 Hospital, Ningbo, People’s Republic of ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaGuangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaAim 2-HP-β-cyclodextrin-PLGA nanoparticle complexes were prepared to enhance the aqueous humour delivery of Triamcinolone acetonide.Materials & methods Drug-loaded 2-HP-β-CD/PLGA nanoparticle complexes prepared by adapting a quasi-emulsion solvent evaporation technique. In vitro drug release, in vitro transcorneal permeation study, histopathological study and in vivo transcorneal penetration of PLGA nanoparticles and 2-HP-β-CD/PLGA nanoparticle complexes were evaluated. Results Particle size distributions of 2-HP-β-CD/PLGA nanoparticle complexes were 149.4 ± 3.7 nm and presented stable system. Corneal penetration studies revealed steady sustained drug release (First-order); 2-HP-β-CD/PLGA nanoparticle complexes increased ocular bioavailability by increasing dispersion in the tear film and improving drug release. Conclusion 2-HP-β-CD/PLGA nanoparticle complex formulation is a promising alternative to conventional eye drops.https://www.tandfonline.com/doi/10.1080/21691401.2019.1683567Hydrophilicityocular drug deliveryPLGA nanoparticlestriamcinolone acetonide2-hydroxypropyl-beta-cyclodextrin |
| spellingShingle | Fan Li Yuqin Wen Yan Zhang Kangyu Zheng Junfeng Ban Qingchun Xie Yifeng Wen Qing Liu Fohua Chen Zhenjie Mo Lizhong Liu Yanzhong Chen Zhufen Lu Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles Artificial Cells, Nanomedicine, and Biotechnology Hydrophilicity ocular drug delivery PLGA nanoparticles triamcinolone acetonide 2-hydroxypropyl-beta-cyclodextrin |
| title | Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles |
| title_full | Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles |
| title_fullStr | Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles |
| title_full_unstemmed | Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles |
| title_short | Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles |
| title_sort | characterisation of 2 hp β cyclodextrin plga nanoparticle complexes for potential use as ocular drug delivery vehicles |
| topic | Hydrophilicity ocular drug delivery PLGA nanoparticles triamcinolone acetonide 2-hydroxypropyl-beta-cyclodextrin |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1683567 |
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