Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function
Males and females respond differently to medications due to physiologic, metabolic, and genetic factors. At times, sex‐related differences cannot be mitigated by dose adjustment to body mass, and are evident from the tissue level to the single cell. The rising number of clinically approved nanotechn...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2022-12-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202200089 |
| _version_ | 1811205322551853056 |
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| author | Maria Poley Gal Chen Noga Sharf-Pauker Aviram Avital Maya Kaduri Mor Sela Patricia Mora Raimundo Lilach Koren Sivan Arber Egor Egorov Janna Shainsky Jeny Shklover Avi Schroeder |
| author_facet | Maria Poley Gal Chen Noga Sharf-Pauker Aviram Avital Maya Kaduri Mor Sela Patricia Mora Raimundo Lilach Koren Sivan Arber Egor Egorov Janna Shainsky Jeny Shklover Avi Schroeder |
| author_sort | Maria Poley |
| collection | DOAJ |
| description | Males and females respond differently to medications due to physiologic, metabolic, and genetic factors. At times, sex‐related differences cannot be mitigated by dose adjustment to body mass, and are evident from the tissue level to the single cell. The rising number of clinically approved nanotechnologies calls for assessing how their activity is affected by the patient's sex. Herein, sex differences in nanotechnology are scoped, with emphasis on molecular considerations. Sex‐specific pharmacokinetics of nanocarriers is influenced by the nanoparticle's composition, its size, and architecture. The biodistribution and immune response to nanoparticles in males and females, and the influence nanoparticles have on hormones, fertility, and toxicity, are discussed. Despite its importance, the effect of sex on the design and implementation of nanomedicines is underresearched. Herein, it is aimed to raise awareness of sex differences in the preclinical and clinical evaluation of nanotechnologies. |
| first_indexed | 2024-04-12T03:30:03Z |
| format | Article |
| id | doaj.art-f2cbb73ba8b34bc5ad30636da92e7fe7 |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-04-12T03:30:03Z |
| publishDate | 2022-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-f2cbb73ba8b34bc5ad30636da92e7fe72022-12-22T03:49:35ZengWiley-VCHAdvanced NanoBiomed Research2699-93072022-12-01212n/an/a10.1002/anbr.202200089Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic FunctionMaria Poley0Gal Chen1Noga Sharf-Pauker2Aviram Avital3Maya Kaduri4Mor Sela5Patricia Mora Raimundo6Lilach Koren7Sivan Arber8Egor Egorov9Janna Shainsky10Jeny Shklover11Avi Schroeder12Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies Department of Chemical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelLaboratory for Targeted Drug Delivery and Personalized Medicine Technologies Department of Chemical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelThe Norman Seiden Multidisciplinary Program for Nanoscience and Nanotechnology Technion – Israel Institute of Technology Haifa 32000 IsraelThe Norman Seiden Multidisciplinary Program for Nanoscience and Nanotechnology Technion – Israel Institute of Technology Haifa 32000 IsraelLaboratory for Targeted Drug Delivery and Personalized Medicine Technologies Department of Chemical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelLaboratory for Targeted Drug Delivery and Personalized Medicine Technologies Department of Chemical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelLaboratory for Targeted Drug Delivery and Personalized Medicine Technologies Department of Chemical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelLaboratory for Targeted Drug Delivery and Personalized Medicine Technologies Department of Chemical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelLaboratory for Targeted Drug Delivery and Personalized Medicine Technologies Department of Chemical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelLaboratory for Targeted Drug Delivery and Personalized Medicine Technologies Department of Chemical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelLaboratory for Targeted Drug Delivery and Personalized Medicine Technologies Department of Chemical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelLaboratory for Targeted Drug Delivery and Personalized Medicine Technologies Department of Chemical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelLaboratory for Targeted Drug Delivery and Personalized Medicine Technologies Department of Chemical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelMales and females respond differently to medications due to physiologic, metabolic, and genetic factors. At times, sex‐related differences cannot be mitigated by dose adjustment to body mass, and are evident from the tissue level to the single cell. The rising number of clinically approved nanotechnologies calls for assessing how their activity is affected by the patient's sex. Herein, sex differences in nanotechnology are scoped, with emphasis on molecular considerations. Sex‐specific pharmacokinetics of nanocarriers is influenced by the nanoparticle's composition, its size, and architecture. The biodistribution and immune response to nanoparticles in males and females, and the influence nanoparticles have on hormones, fertility, and toxicity, are discussed. Despite its importance, the effect of sex on the design and implementation of nanomedicines is underresearched. Herein, it is aimed to raise awareness of sex differences in the preclinical and clinical evaluation of nanotechnologies.https://doi.org/10.1002/anbr.202200089hormonesnanotechnologypharmacokineticssexes |
| spellingShingle | Maria Poley Gal Chen Noga Sharf-Pauker Aviram Avital Maya Kaduri Mor Sela Patricia Mora Raimundo Lilach Koren Sivan Arber Egor Egorov Janna Shainsky Jeny Shklover Avi Schroeder Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function Advanced NanoBiomed Research hormones nanotechnology pharmacokinetics sexes |
| title | Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function |
| title_full | Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function |
| title_fullStr | Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function |
| title_full_unstemmed | Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function |
| title_short | Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function |
| title_sort | sex based differences in the biodistribution of nanoparticles and their effect on hormonal immune and metabolic function |
| topic | hormones nanotechnology pharmacokinetics sexes |
| url | https://doi.org/10.1002/anbr.202200089 |
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