Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis
Ameloblastoma is a rare benign epithelial odontogenic neoplasm, but with great clinical implications, as despite its benignity and slow growth, most cases are locally aggressive with a significant recurrence rate. Histological, cellular, or molecular analyses of its pathogenesis have confirmed the c...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/12/3190 |
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| author | Emiliano Jurado-Castañeda Carla Monserrat Ramírez-Martínez Alejandro Alonso-Moctezuma Jessica Tamara Páramo-Sánchez Diana Ivette Rivera-Reza Osmar Alejandro Chanes-Cuevas César Luis Ortiz-Solís Mario Alberto Téliz-Meneses Oscar Rohel Hernández-Ortega Marco Xavier Vizzuete-Bolaños Patricio Olmedo-Bastidas Luis Fernando Jacinto-Alemán |
| author_facet | Emiliano Jurado-Castañeda Carla Monserrat Ramírez-Martínez Alejandro Alonso-Moctezuma Jessica Tamara Páramo-Sánchez Diana Ivette Rivera-Reza Osmar Alejandro Chanes-Cuevas César Luis Ortiz-Solís Mario Alberto Téliz-Meneses Oscar Rohel Hernández-Ortega Marco Xavier Vizzuete-Bolaños Patricio Olmedo-Bastidas Luis Fernando Jacinto-Alemán |
| author_sort | Emiliano Jurado-Castañeda |
| collection | DOAJ |
| description | Ameloblastoma is a rare benign epithelial odontogenic neoplasm, but with great clinical implications, as despite its benignity and slow growth, most cases are locally aggressive with a significant recurrence rate. Histological, cellular, or molecular analyses of its pathogenesis have confirmed the complexity of this neoplasm. We present the case of a 20-year-old patient with a suggestive clinical and radiographic diagnosis of ameloblastoma. An incisional biopsy was obtained confirming the diagnosis of conventional ameloblastoma. Left hemimandibulectomy and plate reconstruction were performed. Histopathological analysis of the surgical specimen confirmed the conventional ameloblastoma with a plexiform pattern and significant areas of cystic degeneration and amyloid-like-like deposits. Additionally, a microarray was carried out with bioinformatic analysis for the enrichment, protein interaction, and determination of eight hub genes (CRP, BCHE, APP, AKT1, AGT, ACTC1, ADAM10, and APOA2) related to their pathogenesis. |
| first_indexed | 2024-03-09T17:08:52Z |
| format | Article |
| id | doaj.art-f2cd1a2e84c84a878a818e1d8533e8ae |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T17:08:52Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f2cd1a2e84c84a878a818e1d8533e8ae2023-11-24T14:20:15ZengMDPI AGDiagnostics2075-44182022-12-011212319010.3390/diagnostics12123190Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic AnalysisEmiliano Jurado-Castañeda0Carla Monserrat Ramírez-Martínez1Alejandro Alonso-Moctezuma2Jessica Tamara Páramo-Sánchez3Diana Ivette Rivera-Reza4Osmar Alejandro Chanes-Cuevas5César Luis Ortiz-Solís6Mario Alberto Téliz-Meneses7Oscar Rohel Hernández-Ortega8Marco Xavier Vizzuete-Bolaños9Patricio Olmedo-Bastidas10Luis Fernando Jacinto-Alemán11Department of Oral Medicine and Pathology, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, MexicoDepartment of Oral Medicine and Pathology, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, MexicoOral and Maxillofacial Surgery Specialty, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, MexicoDepartment of Oral Medicine and Pathology, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, MexicoDepartment of Oral Medicine and Pathology, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, MexicoDental Biomaterials Laboratory, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, MexicoDepartment of Oral Medicine and Pathology, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, MexicoMaxillofacial Surgery Department, General Hospital of Balbuena, Mexico City 15970, MexicoOral and Maxillofacial Surgery Specialty, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, MexicoOral and Maxillofacial Surgery Specialty, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, MexicoOral and Maxillofacial Surgery Specialty, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, MexicoDepartment of Oral Medicine and Pathology, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, MexicoAmeloblastoma is a rare benign epithelial odontogenic neoplasm, but with great clinical implications, as despite its benignity and slow growth, most cases are locally aggressive with a significant recurrence rate. Histological, cellular, or molecular analyses of its pathogenesis have confirmed the complexity of this neoplasm. We present the case of a 20-year-old patient with a suggestive clinical and radiographic diagnosis of ameloblastoma. An incisional biopsy was obtained confirming the diagnosis of conventional ameloblastoma. Left hemimandibulectomy and plate reconstruction were performed. Histopathological analysis of the surgical specimen confirmed the conventional ameloblastoma with a plexiform pattern and significant areas of cystic degeneration and amyloid-like-like deposits. Additionally, a microarray was carried out with bioinformatic analysis for the enrichment, protein interaction, and determination of eight hub genes (CRP, BCHE, APP, AKT1, AGT, ACTC1, ADAM10, and APOA2) related to their pathogenesis.https://www.mdpi.com/2075-4418/12/12/3190ameloblastomaodontogenic tumorhemimandibulectomymicroarray analysisbioinformatics |
| spellingShingle | Emiliano Jurado-Castañeda Carla Monserrat Ramírez-Martínez Alejandro Alonso-Moctezuma Jessica Tamara Páramo-Sánchez Diana Ivette Rivera-Reza Osmar Alejandro Chanes-Cuevas César Luis Ortiz-Solís Mario Alberto Téliz-Meneses Oscar Rohel Hernández-Ortega Marco Xavier Vizzuete-Bolaños Patricio Olmedo-Bastidas Luis Fernando Jacinto-Alemán Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis Diagnostics ameloblastoma odontogenic tumor hemimandibulectomy microarray analysis bioinformatics |
| title | Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis |
| title_full | Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis |
| title_fullStr | Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis |
| title_full_unstemmed | Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis |
| title_short | Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis |
| title_sort | conventional ameloblastoma a case report with microarray and bioinformatic analysis |
| topic | ameloblastoma odontogenic tumor hemimandibulectomy microarray analysis bioinformatics |
| url | https://www.mdpi.com/2075-4418/12/12/3190 |
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