Structural insights for selective disruption of Beclin 1 binding to Bcl-2

Structural insights for selective disruption of Beclin 1 binding to Bcl-2

Abstract Stimulation of autophagy could provide powerful therapies for multiple diseases, including cancer and neurodegeneration. An attractive drug target for this purpose is Bcl-2, which inhibits autophagy by binding to the Beclin 1 BH3-domain. However, compounds that preclude Beclin 1/Bcl-2 bindi...

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Bibliographic Details
Main Authors:	Yun-Zu Pan, Qiren Liang, Diana R. Tomchick, Jef K. De Brabander, Josep Rizo
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-10-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-023-05467-w

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