Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study

Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study

Hydrazone is a bioactive pharmacophore that can be used to design antitumor agents. We synthesised a series of hydrazones (compounds 4–24) incorporating a 4-methylsulfonylbenzene scaffold and analysed their potential antitumor activity. Compounds 6, 9, 16, and 20 had the most antitumor activity with...

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Bibliographic Details
Main Authors:	Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Nawaf A. AlSaif, Ahmad J. Obaidullah, Abdulrahman M. Al-Obaid, Ibrahim A. Al-Suwaidan
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2021-01-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	hydrazones synthesis antitumor activity cell cycle analysis enzymatic assay cox-2 inhibition egfr inhibition her2 inhibition molecular docking
Online Access:	http://dx.doi.org/10.1080/14756366.2021.1924698

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