Application of Nanoparticles and Melatonin for Cryopreservation of Gametes and Embryos
Cryopreservation of gametes and embryos, a technique widely applied in human infertility clinics and to preserve desirable genetic traits of livestock, has been developed over 30 years as a component of the artificial insemination process. A number of researchers have conducted studies to reduce cel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/9/276 |
| _version_ | 1797489903667249152 |
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| author | Hyun-Woo Choi Hoon Jang |
| author_facet | Hyun-Woo Choi Hoon Jang |
| author_sort | Hyun-Woo Choi |
| collection | DOAJ |
| description | Cryopreservation of gametes and embryos, a technique widely applied in human infertility clinics and to preserve desirable genetic traits of livestock, has been developed over 30 years as a component of the artificial insemination process. A number of researchers have conducted studies to reduce cell toxicity during cryopreservation using adjuvants leading to higher gamete and embryo survival rates. Melatonin and Nanoparticles are novel cryoprotectants and recent studies have investigated their properties such as regulating oxidative stresses, lipid peroxidation, and DNA fragmentation in order to protect gametes and embryos during vitrification. This review presented the current status of cryoprotectants and highlights the novel biomaterials such as melatonin and nanoparticles that may improve the survivability of gametes and embryos during this process. |
| first_indexed | 2024-03-10T00:23:19Z |
| format | Article |
| id | doaj.art-f2d02deb87564d34a455d9b35fede9e1 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-10T00:23:19Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-f2d02deb87564d34a455d9b35fede9e12023-11-23T15:39:10ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-09-014494028404410.3390/cimb44090276Application of Nanoparticles and Melatonin for Cryopreservation of Gametes and EmbryosHyun-Woo Choi0Hoon Jang1Department of Animal Science, Jeonbuk National University, Jeonju 54896, KoreaDepartment of Life Sciences, Jeonbuk National University, Jeonju 54896, KoreaCryopreservation of gametes and embryos, a technique widely applied in human infertility clinics and to preserve desirable genetic traits of livestock, has been developed over 30 years as a component of the artificial insemination process. A number of researchers have conducted studies to reduce cell toxicity during cryopreservation using adjuvants leading to higher gamete and embryo survival rates. Melatonin and Nanoparticles are novel cryoprotectants and recent studies have investigated their properties such as regulating oxidative stresses, lipid peroxidation, and DNA fragmentation in order to protect gametes and embryos during vitrification. This review presented the current status of cryoprotectants and highlights the novel biomaterials such as melatonin and nanoparticles that may improve the survivability of gametes and embryos during this process.https://www.mdpi.com/1467-3045/44/9/276cryopreservationcryoprotectantmelatoninnanoparticlesimproving fertility |
| spellingShingle | Hyun-Woo Choi Hoon Jang Application of Nanoparticles and Melatonin for Cryopreservation of Gametes and Embryos Current Issues in Molecular Biology cryopreservation cryoprotectant melatonin nanoparticles improving fertility |
| title | Application of Nanoparticles and Melatonin for Cryopreservation of Gametes and Embryos |
| title_full | Application of Nanoparticles and Melatonin for Cryopreservation of Gametes and Embryos |
| title_fullStr | Application of Nanoparticles and Melatonin for Cryopreservation of Gametes and Embryos |
| title_full_unstemmed | Application of Nanoparticles and Melatonin for Cryopreservation of Gametes and Embryos |
| title_short | Application of Nanoparticles and Melatonin for Cryopreservation of Gametes and Embryos |
| title_sort | application of nanoparticles and melatonin for cryopreservation of gametes and embryos |
| topic | cryopreservation cryoprotectant melatonin nanoparticles improving fertility |
| url | https://www.mdpi.com/1467-3045/44/9/276 |
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