Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study
Central nervous system inflammation might play a role in patients with depressive disorders. This hypothesis is supported by studies reporting increased cerebrospinal fluid levels of the inflammatory markers interleukin (IL)-6, IL-8 and tumor necrosis factor alpha (TNF-α) in patients with ongoing de...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.947605/full |
| _version_ | 1798003089344561152 |
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| author | Morten Brix Schou Morten Brix Schou Jeanette Brun Larsen Jeanette Brun Larsen Astrid Kamilla Stunes Astrid Kamilla Stunes Sverre Georg Sæther |
| author_facet | Morten Brix Schou Morten Brix Schou Jeanette Brun Larsen Jeanette Brun Larsen Astrid Kamilla Stunes Astrid Kamilla Stunes Sverre Georg Sæther |
| author_sort | Morten Brix Schou |
| collection | DOAJ |
| description | Central nervous system inflammation might play a role in patients with depressive disorders. This hypothesis is supported by studies reporting increased cerebrospinal fluid levels of the inflammatory markers interleukin (IL)-6, IL-8 and tumor necrosis factor alpha (TNF-α) in patients with ongoing depression. In this case-control study, we aimed to examine whether these findings also applied to depressed patients in a geriatric population. Cerebrospinal fluid cytokine analyses were performed on 15 patients (age >60 years) with depressive disorders and 45 age– and sex matched controls (patients with headache or idiopathic facial palsy). IL-6, IL-8, IL-10, TNF-α, monocyte chemoattractant protein-1 and transforming growth factor beta 1 were included in the statistical analyses. Patients with depression had significantly lower cerebrospinal fluid levels of IL-6 as compared to controls (p = 0.014) in the univariate analysis. The finding was, however, no longer statistically significant after correction for age and body mass index (p = 0.097). Overall, this study indicates that the cytokines included in this study are not significantly altered in geriatric patients with depression. Future studies exploring cerebrospinal fluid cytokine levels should include corrections for possible confounding factors. |
| first_indexed | 2024-04-11T12:03:33Z |
| format | Article |
| id | doaj.art-f2d2d6e72e1848909f5a555f39ae287e |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T12:03:33Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-f2d2d6e72e1848909f5a555f39ae287e2022-12-22T04:24:48ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-09-011310.3389/fpsyt.2022.947605947605Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control studyMorten Brix Schou0Morten Brix Schou1Jeanette Brun Larsen2Jeanette Brun Larsen3Astrid Kamilla Stunes4Astrid Kamilla Stunes5Sverre Georg Sæther6Department of Mental Healthcare - General, Rehabilitation and Safety, St Olav's University Hospital, Trondheim, NorwayDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Mental Healthcare - General, Rehabilitation and Safety, St Olav's University Hospital, Trondheim, NorwayDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, NorwayMedical Clinic, St. Olavs University Hospital, Trondheim, NorwayBlue Cross Lade Addiction Treatment Centre, Trondheim, NorwayCentral nervous system inflammation might play a role in patients with depressive disorders. This hypothesis is supported by studies reporting increased cerebrospinal fluid levels of the inflammatory markers interleukin (IL)-6, IL-8 and tumor necrosis factor alpha (TNF-α) in patients with ongoing depression. In this case-control study, we aimed to examine whether these findings also applied to depressed patients in a geriatric population. Cerebrospinal fluid cytokine analyses were performed on 15 patients (age >60 years) with depressive disorders and 45 age– and sex matched controls (patients with headache or idiopathic facial palsy). IL-6, IL-8, IL-10, TNF-α, monocyte chemoattractant protein-1 and transforming growth factor beta 1 were included in the statistical analyses. Patients with depression had significantly lower cerebrospinal fluid levels of IL-6 as compared to controls (p = 0.014) in the univariate analysis. The finding was, however, no longer statistically significant after correction for age and body mass index (p = 0.097). Overall, this study indicates that the cytokines included in this study are not significantly altered in geriatric patients with depression. Future studies exploring cerebrospinal fluid cytokine levels should include corrections for possible confounding factors.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.947605/fullneuroinflammationcytokine—immunological termscerebrospinal fluidaffective disordersdepression |
| spellingShingle | Morten Brix Schou Morten Brix Schou Jeanette Brun Larsen Jeanette Brun Larsen Astrid Kamilla Stunes Astrid Kamilla Stunes Sverre Georg Sæther Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study Frontiers in Psychiatry neuroinflammation cytokine—immunological terms cerebrospinal fluid affective disorders depression |
| title | Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study |
| title_full | Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study |
| title_fullStr | Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study |
| title_full_unstemmed | Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study |
| title_short | Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study |
| title_sort | cerebrospinal fluid cytokines in geriatric patients with depressive disorders a retrospective case control study |
| topic | neuroinflammation cytokine—immunological terms cerebrospinal fluid affective disorders depression |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.947605/full |
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