The Challenges of The Diagnostic and Therapeutic Approach of Patients with Infectious Pathology in Emergency Medicine
The emergency department (ED) represents an important setting for addressing inappropriate antimicrobial prescribing practices because of the time constraints and the duration of microbiological diagnosis. The purpose of this study is to evaluate the etiology and antimicrobial resistance (AMR) patte...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/14/1/46 |
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| author | Silvia Ioana Musuroi Adela Voinescu Corina Musuroi Luminita Mirela Baditoiu Delia Muntean Oana Izmendi Romanita Jumanca Monica Licker |
| author_facet | Silvia Ioana Musuroi Adela Voinescu Corina Musuroi Luminita Mirela Baditoiu Delia Muntean Oana Izmendi Romanita Jumanca Monica Licker |
| author_sort | Silvia Ioana Musuroi |
| collection | DOAJ |
| description | The emergency department (ED) represents an important setting for addressing inappropriate antimicrobial prescribing practices because of the time constraints and the duration of microbiological diagnosis. The purpose of this study is to evaluate the etiology and antimicrobial resistance (AMR) pattern of the community-acquired pathogens, as well as the epidemiological characteristics of patients admitted through the ED, in order to guide appropriate antibiotic therapy. Methods: A retrospective observational study was performed on 657 patients, from whom clinical samples (urine, purulent secretions, blood cultures, etc.) were collected for microbiological diagnosis in the first 3 days after presentation in the ED. The identification of pathogens and the antimicrobial susceptibility testing with minimum inhibitory concentration determination were carried out according to the laboratory protocols. Results: From the 767 biological samples analyzed, 903 microbial isolates were identified. <i>E. coli</i> was most frequently isolated (24.25%), followed by <i>Klebsiella</i> spp., <i>S. aureus</i> (SA), and non-fermentative Gram-negative bacilli. <i>E. coli</i> strains maintained their natural susceptibility to most antibiotics tested. In the case of <i>Pseudomonas</i> spp. and <i>Acinetobacter</i> spp., increased rates of AMR were identified. Also, 32.3% of SA strains were community-acquired MRSA. Conclusions: The introduction of rapid microbiological diagnostic methods in emergency medicine is imperative in order to timely identify AMR strains and improve therapeutic protocols. |
| first_indexed | 2024-03-08T10:45:49Z |
| format | Article |
| id | doaj.art-f2d407bfe38444918b0264736c111509 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-08T10:45:49Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-f2d407bfe38444918b0264736c1115092024-01-26T17:19:23ZengMDPI AGJournal of Personalized Medicine2075-44262023-12-011414610.3390/jpm14010046The Challenges of The Diagnostic and Therapeutic Approach of Patients with Infectious Pathology in Emergency MedicineSilvia Ioana Musuroi0Adela Voinescu1Corina Musuroi2Luminita Mirela Baditoiu3Delia Muntean4Oana Izmendi5Romanita Jumanca6Monica Licker7Doctoral School, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDoctoral School, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaMicrobiology Department, Multidisciplinary Research Center of Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaEpidemiology Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaMicrobiology Department, Multidisciplinary Research Center of Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDoctoral School, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaRomanian and Foreign Languages Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaMicrobiology Department, Multidisciplinary Research Center of Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaThe emergency department (ED) represents an important setting for addressing inappropriate antimicrobial prescribing practices because of the time constraints and the duration of microbiological diagnosis. The purpose of this study is to evaluate the etiology and antimicrobial resistance (AMR) pattern of the community-acquired pathogens, as well as the epidemiological characteristics of patients admitted through the ED, in order to guide appropriate antibiotic therapy. Methods: A retrospective observational study was performed on 657 patients, from whom clinical samples (urine, purulent secretions, blood cultures, etc.) were collected for microbiological diagnosis in the first 3 days after presentation in the ED. The identification of pathogens and the antimicrobial susceptibility testing with minimum inhibitory concentration determination were carried out according to the laboratory protocols. Results: From the 767 biological samples analyzed, 903 microbial isolates were identified. <i>E. coli</i> was most frequently isolated (24.25%), followed by <i>Klebsiella</i> spp., <i>S. aureus</i> (SA), and non-fermentative Gram-negative bacilli. <i>E. coli</i> strains maintained their natural susceptibility to most antibiotics tested. In the case of <i>Pseudomonas</i> spp. and <i>Acinetobacter</i> spp., increased rates of AMR were identified. Also, 32.3% of SA strains were community-acquired MRSA. Conclusions: The introduction of rapid microbiological diagnostic methods in emergency medicine is imperative in order to timely identify AMR strains and improve therapeutic protocols.https://www.mdpi.com/2075-4426/14/1/46<i>Pseudomonas</i><i>Acinetobacter</i>antibiotic |
| spellingShingle | Silvia Ioana Musuroi Adela Voinescu Corina Musuroi Luminita Mirela Baditoiu Delia Muntean Oana Izmendi Romanita Jumanca Monica Licker The Challenges of The Diagnostic and Therapeutic Approach of Patients with Infectious Pathology in Emergency Medicine Journal of Personalized Medicine <i>Pseudomonas</i> <i>Acinetobacter</i> antibiotic |
| title | The Challenges of The Diagnostic and Therapeutic Approach of Patients with Infectious Pathology in Emergency Medicine |
| title_full | The Challenges of The Diagnostic and Therapeutic Approach of Patients with Infectious Pathology in Emergency Medicine |
| title_fullStr | The Challenges of The Diagnostic and Therapeutic Approach of Patients with Infectious Pathology in Emergency Medicine |
| title_full_unstemmed | The Challenges of The Diagnostic and Therapeutic Approach of Patients with Infectious Pathology in Emergency Medicine |
| title_short | The Challenges of The Diagnostic and Therapeutic Approach of Patients with Infectious Pathology in Emergency Medicine |
| title_sort | challenges of the diagnostic and therapeutic approach of patients with infectious pathology in emergency medicine |
| topic | <i>Pseudomonas</i> <i>Acinetobacter</i> antibiotic |
| url | https://www.mdpi.com/2075-4426/14/1/46 |
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