Cisplatin Reduces the Frequencies of Radiotherapy-Induced Micronuclei in Peripheral Blood Lymphocytes of Patients with Gynaecological Cancer: Possible Implications for the Risk of Second Malignant Neoplasms

Cisplatin Reduces the Frequencies of Radiotherapy-Induced Micronuclei in Peripheral Blood Lymphocytes of Patients with Gynaecological Cancer: Possible Implications for the Risk of Second Malignant Neoplasms

Gynaecologic cancers are common among women and treatment includes surgery, radiotherapy or chemotherapy, where the last two methods induce DNA damage in non-targeted cells like peripheral blood lymphocytes (PBL). Damaged normal cells can transform leading to second malignant neoplasms (SMN) but the...

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Bibliographic Details
Main Authors: Aneta Węgierek-Ciuk, Anna Lankoff, Halina Lisowska, Piotr Kędzierawski, Pamela Akuwudike, Lovisa Lundholm, Andrzej Wojcik
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
radiotherapy
chemotherapy
chromosomal damage
apoptosis
second primary cancers
second malignant neoplasms
Online Access:https://www.mdpi.com/2073-4409/10/10/2709

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