Psychiatric symptoms and risk factors in adults born preterm with very low birthweight or born small for gestational age at term
Abstract Background We aimed to examine psychiatric symptoms in adults born preterm with very low birthweight or born at term small for gestational age compared with normal birthweight peers, and examine associations with perinatal factors and childhood motor and cognitive function. Methods In this...
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| Format: | Article |
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BMC
2019-07-01
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| Series: | BMC Psychiatry |
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| Online Access: | http://link.springer.com/article/10.1186/s12888-019-2202-8 |
| _version_ | 1818116961415987200 |
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| author | Astrid M. W. Lærum Solveig Klæbo Reitan Kari Anne I. Evensen Stian Lydersen Ann-Mari Brubakk Jon Skranes Marit S. Indredavik |
| author_facet | Astrid M. W. Lærum Solveig Klæbo Reitan Kari Anne I. Evensen Stian Lydersen Ann-Mari Brubakk Jon Skranes Marit S. Indredavik |
| author_sort | Astrid M. W. Lærum |
| collection | DOAJ |
| description | Abstract Background We aimed to examine psychiatric symptoms in adults born preterm with very low birthweight or born at term small for gestational age compared with normal birthweight peers, and examine associations with perinatal factors and childhood motor and cognitive function. Methods In this longitudinal cohort study, one preterm born group with very low birthweight (VLBW: birthweight ≤1500 g), one term-born Small for Gestational Age (SGA: birthweight <10th percentile) group and one term-born non-SGA control group, were assessed at 26 years of age. Primary outcomes were scores on self-reported questionnaires: Achenbach System of Empirically Based Assessment - Adult Self-Report, The Autism-Spectrum Quotient and Peters et al. Delusions Inventory. Exposure variables were perinatal data, while childhood motor and cognitive function were examined as possible early markers. Results Both the preterm VLBW and the term SGA group reported higher levels of attention, internalizing and externalizing problems compared to the control group. In addition, the VLBW participants reported more critical items and a higher proportion had intermediate level autistic traits, while the SGA participants reported more intrusive behavior. Increasing length of respiratory support and hospital stay in the neonatal period, and motor problems in early adolescence, were associated with adult psychiatric symptoms in the VLBW group. Conclusions Psychiatric symptoms were frequent in the preterm VLBW group and also in the term-born SGA group. Those who were sickest as babies were most at risk. Motor problems can possibly serve as an early marker of adult psychiatric symptoms in low birthweight individuals. |
| first_indexed | 2024-12-11T04:30:50Z |
| format | Article |
| id | doaj.art-f2d8adc6e98a43d5918767433ffa0676 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-11T04:30:50Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-f2d8adc6e98a43d5918767433ffa06762022-12-22T01:20:52ZengBMCBMC Psychiatry1471-244X2019-07-0119111410.1186/s12888-019-2202-8Psychiatric symptoms and risk factors in adults born preterm with very low birthweight or born small for gestational age at termAstrid M. W. Lærum0Solveig Klæbo Reitan1Kari Anne I. Evensen2Stian Lydersen3Ann-Mari Brubakk4Jon Skranes5Marit S. Indredavik6Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyDepartment of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyDepartment of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyAbstract Background We aimed to examine psychiatric symptoms in adults born preterm with very low birthweight or born at term small for gestational age compared with normal birthweight peers, and examine associations with perinatal factors and childhood motor and cognitive function. Methods In this longitudinal cohort study, one preterm born group with very low birthweight (VLBW: birthweight ≤1500 g), one term-born Small for Gestational Age (SGA: birthweight <10th percentile) group and one term-born non-SGA control group, were assessed at 26 years of age. Primary outcomes were scores on self-reported questionnaires: Achenbach System of Empirically Based Assessment - Adult Self-Report, The Autism-Spectrum Quotient and Peters et al. Delusions Inventory. Exposure variables were perinatal data, while childhood motor and cognitive function were examined as possible early markers. Results Both the preterm VLBW and the term SGA group reported higher levels of attention, internalizing and externalizing problems compared to the control group. In addition, the VLBW participants reported more critical items and a higher proportion had intermediate level autistic traits, while the SGA participants reported more intrusive behavior. Increasing length of respiratory support and hospital stay in the neonatal period, and motor problems in early adolescence, were associated with adult psychiatric symptoms in the VLBW group. Conclusions Psychiatric symptoms were frequent in the preterm VLBW group and also in the term-born SGA group. Those who were sickest as babies were most at risk. Motor problems can possibly serve as an early marker of adult psychiatric symptoms in low birthweight individuals.http://link.springer.com/article/10.1186/s12888-019-2202-8Low birthweightMental healthPsychiatric symptomsRisk factorsAutism |
| spellingShingle | Astrid M. W. Lærum Solveig Klæbo Reitan Kari Anne I. Evensen Stian Lydersen Ann-Mari Brubakk Jon Skranes Marit S. Indredavik Psychiatric symptoms and risk factors in adults born preterm with very low birthweight or born small for gestational age at term BMC Psychiatry Low birthweight Mental health Psychiatric symptoms Risk factors Autism |
| title | Psychiatric symptoms and risk factors in adults born preterm with very low birthweight or born small for gestational age at term |
| title_full | Psychiatric symptoms and risk factors in adults born preterm with very low birthweight or born small for gestational age at term |
| title_fullStr | Psychiatric symptoms and risk factors in adults born preterm with very low birthweight or born small for gestational age at term |
| title_full_unstemmed | Psychiatric symptoms and risk factors in adults born preterm with very low birthweight or born small for gestational age at term |
| title_short | Psychiatric symptoms and risk factors in adults born preterm with very low birthweight or born small for gestational age at term |
| title_sort | psychiatric symptoms and risk factors in adults born preterm with very low birthweight or born small for gestational age at term |
| topic | Low birthweight Mental health Psychiatric symptoms Risk factors Autism |
| url | http://link.springer.com/article/10.1186/s12888-019-2202-8 |
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