Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives
Potent, cell-permeable, and subtype-selective sialyltransferase inhibitors represent an attractive family of substances that can potentially be used for the clinical treatment of cancer metastasis. These substances operate by specifically inhibiting sialyltransferase-mediated hypersialylation of cel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/18/5673 |
| _version_ | 1797517977438912512 |
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| author | Ser John Lynon P. Perez Chih-Wei Fu Wen-Shan Li |
| author_facet | Ser John Lynon P. Perez Chih-Wei Fu Wen-Shan Li |
| author_sort | Ser John Lynon P. Perez |
| collection | DOAJ |
| description | Potent, cell-permeable, and subtype-selective sialyltransferase inhibitors represent an attractive family of substances that can potentially be used for the clinical treatment of cancer metastasis. These substances operate by specifically inhibiting sialyltransferase-mediated hypersialylation of cell surface glycoproteins or glycolipids, which then blocks the sialic acid recognition pathway and leads to deterioration of cell motility and invasion. A vast amount of evidence for the in vitro and in vivo effects of sialyltransferase inhibition or knockdown on tumor progression and tumor cell metastasis or colonization has been accumulated over the past decades. In this regard, this review comprehensively discusses the results of studies that have led to the recent discovery and development of sialyltransferase inhibitors, their potential biomedical applications in the treatment of cancer metastasis, and their current limitations and future opportunities. |
| first_indexed | 2024-03-10T07:23:43Z |
| format | Article |
| id | doaj.art-f2daf7a4635545c89467fbd7ed6baa61 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T07:23:43Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f2daf7a4635545c89467fbd7ed6baa612023-11-22T14:26:45ZengMDPI AGMolecules1420-30492021-09-012618567310.3390/molecules26185673Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future PerspectivesSer John Lynon P. Perez0Chih-Wei Fu1Wen-Shan Li2Institute of Chemistry, Academia Sinica, Taipei 115, TaiwanInstitute of Chemistry, Academia Sinica, Taipei 115, TaiwanInstitute of Chemistry, Academia Sinica, Taipei 115, TaiwanPotent, cell-permeable, and subtype-selective sialyltransferase inhibitors represent an attractive family of substances that can potentially be used for the clinical treatment of cancer metastasis. These substances operate by specifically inhibiting sialyltransferase-mediated hypersialylation of cell surface glycoproteins or glycolipids, which then blocks the sialic acid recognition pathway and leads to deterioration of cell motility and invasion. A vast amount of evidence for the in vitro and in vivo effects of sialyltransferase inhibition or knockdown on tumor progression and tumor cell metastasis or colonization has been accumulated over the past decades. In this regard, this review comprehensively discusses the results of studies that have led to the recent discovery and development of sialyltransferase inhibitors, their potential biomedical applications in the treatment of cancer metastasis, and their current limitations and future opportunities.https://www.mdpi.com/1420-3049/26/18/5673sialyltransferasehypersialylationcancer metastasissialyltransferase inhibitorsdrug design and development |
| spellingShingle | Ser John Lynon P. Perez Chih-Wei Fu Wen-Shan Li Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives Molecules sialyltransferase hypersialylation cancer metastasis sialyltransferase inhibitors drug design and development |
| title | Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives |
| title_full | Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives |
| title_fullStr | Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives |
| title_full_unstemmed | Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives |
| title_short | Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives |
| title_sort | sialyltransferase inhibitors for the treatment of cancer metastasis current challenges and future perspectives |
| topic | sialyltransferase hypersialylation cancer metastasis sialyltransferase inhibitors drug design and development |
| url | https://www.mdpi.com/1420-3049/26/18/5673 |
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