The Role of Glial Cells in Regulating Feeding Behavior: Potential Relevance to Anorexia Nervosa
Eating behavior is controlled by hypothalamic circuits in which agouti-related peptide-expressing neurons when activated in the arcuate nucleus, promote food intake while pro-opiomelanocortin-producing neurons promote satiety. The respective neurotransmitters signal to other parts of the hypothalamu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/1/186 |
| _version_ | 1797498640000876544 |
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| author | Linda Frintrop Stefanie Trinh Jochen Seitz Markus Kipp |
| author_facet | Linda Frintrop Stefanie Trinh Jochen Seitz Markus Kipp |
| author_sort | Linda Frintrop |
| collection | DOAJ |
| description | Eating behavior is controlled by hypothalamic circuits in which agouti-related peptide-expressing neurons when activated in the arcuate nucleus, promote food intake while pro-opiomelanocortin-producing neurons promote satiety. The respective neurotransmitters signal to other parts of the hypothalamus such as the paraventricular nucleus as well as several extra-hypothalamic brain regions to orchestrate eating behavior. This complex process of food intake may be influenced by glia cells, in particular astrocytes and microglia. Recent studies showed that GFAP<sup>+</sup> astrocyte cell density is reduced in the central nervous system of an experimental anorexia nervosa model. Anorexia nervosa is an eating disorder that causes, among the well-known somatic symptoms, brain volume loss which was associated with neuropsychological deficits while the underlying pathophysiology is unknown. In this review article, we summarize the findings of glia cells in anorexia nervosa animal models and try to deduce which role glia cells might play in the pathophysiology of eating disorders, including anorexia nervosa. A better understanding of glia cell function in the regulation of food intake and eating behavior might lead to the identification of new drug targets. |
| first_indexed | 2024-03-10T03:36:13Z |
| format | Article |
| id | doaj.art-f2dd21b784754f40b5ba5ae5cbb2f111 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:36:13Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f2dd21b784754f40b5ba5ae5cbb2f1112023-11-23T11:44:57ZengMDPI AGJournal of Clinical Medicine2077-03832021-12-0111118610.3390/jcm11010186The Role of Glial Cells in Regulating Feeding Behavior: Potential Relevance to Anorexia NervosaLinda Frintrop0Stefanie Trinh1Jochen Seitz2Markus Kipp3Institute of Anatomy, Rostock University Medical Center, 18057 Rostock, GermanyInstitute of Neuroanatomy, RWTH Aachen University, 52074 Aachen, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, 52074 Aachen, GermanyInstitute of Anatomy, Rostock University Medical Center, 18057 Rostock, GermanyEating behavior is controlled by hypothalamic circuits in which agouti-related peptide-expressing neurons when activated in the arcuate nucleus, promote food intake while pro-opiomelanocortin-producing neurons promote satiety. The respective neurotransmitters signal to other parts of the hypothalamus such as the paraventricular nucleus as well as several extra-hypothalamic brain regions to orchestrate eating behavior. This complex process of food intake may be influenced by glia cells, in particular astrocytes and microglia. Recent studies showed that GFAP<sup>+</sup> astrocyte cell density is reduced in the central nervous system of an experimental anorexia nervosa model. Anorexia nervosa is an eating disorder that causes, among the well-known somatic symptoms, brain volume loss which was associated with neuropsychological deficits while the underlying pathophysiology is unknown. In this review article, we summarize the findings of glia cells in anorexia nervosa animal models and try to deduce which role glia cells might play in the pathophysiology of eating disorders, including anorexia nervosa. A better understanding of glia cell function in the regulation of food intake and eating behavior might lead to the identification of new drug targets.https://www.mdpi.com/2077-0383/11/1/186anorexia nervosaglia cellsastrocytehypothalamus |
| spellingShingle | Linda Frintrop Stefanie Trinh Jochen Seitz Markus Kipp The Role of Glial Cells in Regulating Feeding Behavior: Potential Relevance to Anorexia Nervosa Journal of Clinical Medicine anorexia nervosa glia cells astrocyte hypothalamus |
| title | The Role of Glial Cells in Regulating Feeding Behavior: Potential Relevance to Anorexia Nervosa |
| title_full | The Role of Glial Cells in Regulating Feeding Behavior: Potential Relevance to Anorexia Nervosa |
| title_fullStr | The Role of Glial Cells in Regulating Feeding Behavior: Potential Relevance to Anorexia Nervosa |
| title_full_unstemmed | The Role of Glial Cells in Regulating Feeding Behavior: Potential Relevance to Anorexia Nervosa |
| title_short | The Role of Glial Cells in Regulating Feeding Behavior: Potential Relevance to Anorexia Nervosa |
| title_sort | role of glial cells in regulating feeding behavior potential relevance to anorexia nervosa |
| topic | anorexia nervosa glia cells astrocyte hypothalamus |
| url | https://www.mdpi.com/2077-0383/11/1/186 |
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