The Role of HSA21 Encoded Mirna in Down Syndrome Pathophysiology:Opportunities in miRNA-Targeted Pharmacotherapy and Diagnosis of the Down Syndrome

The Role of HSA21 Encoded Mirna in Down Syndrome Pathophysiology:Opportunities in miRNA-Targeted Pharmacotherapy and Diagnosis of the Down Syndrome

Trisomy 21 is the most prevalent aneuploidy disorder among live-born children worldwide. Itresults from the presence of an extra copy of chromosome 21 which leads to a wide spectrum ofpathophysiological abnormalities and intellectual disabilities. Nevertheless human chromosome21 (HSA21) possess prot...

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Bibliographic Details
Main Authors: Shabnam Mahernia, Sajad Sarvari, Yousef Fatahi, Massoud Amanlou
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2021-09-01
Series:Pharmaceutical Sciences
Subjects:
down syndrome
parthenogenesis
trisomy 21
micrornas
prenatal diagnostic
Online Access:https://ps.tbzmed.ac.ir/PDF/ps-27-302.pdf

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