PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Chronic obstructive pulmonary disease (COPD) is an obstructive pulmonary disorder which is characterized by limitation of expiratory airflow that is not fully reversible. The airflow limitation is usually progressive and is associated with an abnormal inflammatory response of the lungs to noxious pa...
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| Format: | Article |
| Language: | English |
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University in Nis, Faculty of Medicine
2006-01-01
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| Series: | Acta Medica Medianae |
| Subjects: | |
| Online Access: | http://publisher.medfak.ni.ac.rs/2006-html/1-broj/Patogeneza%20hronicne...pdf |
| _version_ | 1811260764698181632 |
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| author | Snezana Cekic Boris Djindjic Milos Filipovic |
| author_facet | Snezana Cekic Boris Djindjic Milos Filipovic |
| author_sort | Snezana Cekic |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is an obstructive pulmonary disorder which is characterized by limitation of expiratory airflow that is not fully reversible. The airflow limitation is usually progressive and is associated with an abnormal inflammatory response of the lungs to noxious particles or gases, primarily caused by cigarette smoking. The inflammatory process associated with COPD is characterized by increased number of activated alveolar macrophages, neutrophils, CD8+ cytotoxic T lymphocytes, B lymphocytes and CD4+ T lymphocytes, and the release of numerous inflammatory mediators (leukotrienes, cytokines, growth factors, chemokines, oxidants and proteases). Chronic inflammation causes remodeling of the small airways with the luminal obstruction due to increased mucus production and thickened walls due to edema and collagen formation that cause fibrosis and narrowing of small airways. Persistent inflammation also leads to destruction of lung tissue, loss of alveolar attachment to the small airways, and decreased lung elastic recoil. Although COPD affects the lungs, it also produces significant systemic consequences. |
| first_indexed | 2024-04-12T18:52:29Z |
| format | Article |
| id | doaj.art-f2e46077da174e3ea41f2f615626b12e |
| institution | Directory Open Access Journal |
| issn | 0365-4478 |
| language | English |
| last_indexed | 2024-04-12T18:52:29Z |
| publishDate | 2006-01-01 |
| publisher | University in Nis, Faculty of Medicine |
| record_format | Article |
| series | Acta Medica Medianae |
| spelling | doaj.art-f2e46077da174e3ea41f2f615626b12e2022-12-22T03:20:26ZengUniversity in Nis, Faculty of MedicineActa Medica Medianae0365-44782006-01-014517381PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASESnezana CekicBoris DjindjicMilos FilipovicChronic obstructive pulmonary disease (COPD) is an obstructive pulmonary disorder which is characterized by limitation of expiratory airflow that is not fully reversible. The airflow limitation is usually progressive and is associated with an abnormal inflammatory response of the lungs to noxious particles or gases, primarily caused by cigarette smoking. The inflammatory process associated with COPD is characterized by increased number of activated alveolar macrophages, neutrophils, CD8+ cytotoxic T lymphocytes, B lymphocytes and CD4+ T lymphocytes, and the release of numerous inflammatory mediators (leukotrienes, cytokines, growth factors, chemokines, oxidants and proteases). Chronic inflammation causes remodeling of the small airways with the luminal obstruction due to increased mucus production and thickened walls due to edema and collagen formation that cause fibrosis and narrowing of small airways. Persistent inflammation also leads to destruction of lung tissue, loss of alveolar attachment to the small airways, and decreased lung elastic recoil. Although COPD affects the lungs, it also produces significant systemic consequences.http://publisher.medfak.ni.ac.rs/2006-html/1-broj/Patogeneza%20hronicne...pdfbronchitisemphysemacigarette smokingproteasematrix metalloproteinasesoxidative stressalveolar macrophageneutrophilcytokinemucociliary |
| spellingShingle | Snezana Cekic Boris Djindjic Milos Filipovic PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE Acta Medica Medianae bronchitis emphysema cigarette smoking protease matrix metalloproteinases oxidative stress alveolar macrophage neutrophil cytokine mucociliary |
| title | PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full | PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_fullStr | PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full_unstemmed | PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_short | PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_sort | pathogenesis of chronic obstructive pulmonary disease |
| topic | bronchitis emphysema cigarette smoking protease matrix metalloproteinases oxidative stress alveolar macrophage neutrophil cytokine mucociliary |
| url | http://publisher.medfak.ni.ac.rs/2006-html/1-broj/Patogeneza%20hronicne...pdf |
| work_keys_str_mv | AT snezanacekic pathogenesisofchronicobstructivepulmonarydisease AT borisdjindjic pathogenesisofchronicobstructivepulmonarydisease AT milosfilipovic pathogenesisofchronicobstructivepulmonarydisease |