D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet

D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet

LDL receptor-null mice on a Western diet (WD) have inflammation in large arteries and endothelial dysfunction in small arteries, which are improved with the apolipoprotein A-I mimetic D-4F. The role of hyperlipidemia in causing inflammation of very small vessels such as brain arterioles has not prev...

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Bibliographic Details
Main Authors: Georgette M. Buga, Joy S. Frank, Giuliano A. Mottino, Michael Hendizadeh, Ashkan Hakhamian, Jan H. Tillisch, Srinivasa T. Reddy, Mohamad Navab, G.M. Anantharamaiah, Louis J. Ignarro, Alan M. Fogelman
Format: Article
Language:English
Published: Elsevier 2006-10-01
Series:Journal of Lipid Research
Subjects:
hyperlipidemia
lipoproteins
apolipoprotein A-I mimetic peptides
arterioles
brain function
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520434029

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http://www.sciencedirect.com/science/article/pii/S0022227520434029

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