Default mode network connectivity and treatment response in geriatric depression
Abstract Objectives Default mode network (DMN) connectivity is altered in depression. We evaluated the relationship between changes in within‐network DMN connectivity and improvement in depression in a subsample of our parent clinical trial comparing escitalopram/memantine (ESC/MEM) to escitalopram/...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-04-01
|
| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2475 |
| _version_ | 1827860795683241984 |
|---|---|
| author | Lisa A. Kilpatrick Beatrix Krause‐Sorio Prabha Siddarth Katherine L. Narr Helen Lavretsky |
| author_facet | Lisa A. Kilpatrick Beatrix Krause‐Sorio Prabha Siddarth Katherine L. Narr Helen Lavretsky |
| author_sort | Lisa A. Kilpatrick |
| collection | DOAJ |
| description | Abstract Objectives Default mode network (DMN) connectivity is altered in depression. We evaluated the relationship between changes in within‐network DMN connectivity and improvement in depression in a subsample of our parent clinical trial comparing escitalopram/memantine (ESC/MEM) to escitalopram/placebo (ESC/PBO) in older depressed adults (NCT01902004). Methods Twenty‐six participants with major depression (age > 60 years) and subjective memory complaints underwent treatment with ESC/MEM (n = 13) or ESC/PBO (n = 13), and completed baseline and 3‐month follow‐up resting state magnetic resonance imaging scans. Multi‐block partial least squares correlation analysis was used to evaluate the impact of treatment on within‐network DMN connectivity changes and their relationship with symptom improvement at 3 months (controlling for age and sex). Results A significant latent variable was identified, reflecting within‐network DMN connectivity changes correlated with symptom improvement (p = .01). Specifically, although overall group differences in within‐network DMN connectivity changes failed to reach significance, increased within‐network connectivity of posterior/lateral DMN regions (precuneus, angular gyrus, superior/middle temporal cortex) was more strongly and positively correlated with symptom improvement in the ESC/MEM group (r = 0.97, 95% confidence interval: 0.86–0.98) than in the ESC/PBO group (r = 0.36, 95% confidence interval: 0.13–0.72). Conclusions Increased within‐network connectivity of core DMN nodes was more strongly correlated with depressive symptom improvement with ESC/MEM than with ESC/PBO, supporting an improved engagement of brain circuitry implicated in the amelioration of depressive symptoms with combined ESC/MEM treatment in older adults with depression and subjective memory complaints. |
| first_indexed | 2024-03-12T13:27:01Z |
| format | Article |
| id | doaj.art-f2e483e0478a4ae182d0d6cccf2cee7f |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T13:27:01Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-f2e483e0478a4ae182d0d6cccf2cee7f2023-08-25T04:42:41ZengWileyBrain and Behavior2162-32792022-04-01124n/an/a10.1002/brb3.2475Default mode network connectivity and treatment response in geriatric depressionLisa A. Kilpatrick0Beatrix Krause‐Sorio1Prabha Siddarth2Katherine L. Narr3Helen Lavretsky4G. Oppenheimer Family Center for Neurobiology of Stress and Resilience Vatche and Tamar Manoukian Division of Digestive Diseases David Geffen School of Medicine at University of California Los Angeles California USAJane and Terry Semel Institute for Neuroscience and Human Behavior University of California Los Angeles California USAJane and Terry Semel Institute for Neuroscience and Human Behavior University of California Los Angeles California USABrain Mapping Center Departments of Neurology and Psychiatry and Biobehavioral Sciences Los Angeles California USAJane and Terry Semel Institute for Neuroscience and Human Behavior University of California Los Angeles California USAAbstract Objectives Default mode network (DMN) connectivity is altered in depression. We evaluated the relationship between changes in within‐network DMN connectivity and improvement in depression in a subsample of our parent clinical trial comparing escitalopram/memantine (ESC/MEM) to escitalopram/placebo (ESC/PBO) in older depressed adults (NCT01902004). Methods Twenty‐six participants with major depression (age > 60 years) and subjective memory complaints underwent treatment with ESC/MEM (n = 13) or ESC/PBO (n = 13), and completed baseline and 3‐month follow‐up resting state magnetic resonance imaging scans. Multi‐block partial least squares correlation analysis was used to evaluate the impact of treatment on within‐network DMN connectivity changes and their relationship with symptom improvement at 3 months (controlling for age and sex). Results A significant latent variable was identified, reflecting within‐network DMN connectivity changes correlated with symptom improvement (p = .01). Specifically, although overall group differences in within‐network DMN connectivity changes failed to reach significance, increased within‐network connectivity of posterior/lateral DMN regions (precuneus, angular gyrus, superior/middle temporal cortex) was more strongly and positively correlated with symptom improvement in the ESC/MEM group (r = 0.97, 95% confidence interval: 0.86–0.98) than in the ESC/PBO group (r = 0.36, 95% confidence interval: 0.13–0.72). Conclusions Increased within‐network connectivity of core DMN nodes was more strongly correlated with depressive symptom improvement with ESC/MEM than with ESC/PBO, supporting an improved engagement of brain circuitry implicated in the amelioration of depressive symptoms with combined ESC/MEM treatment in older adults with depression and subjective memory complaints.https://doi.org/10.1002/brb3.2475default mode networkdepressionmemoryrandomized controlled trial |
| spellingShingle | Lisa A. Kilpatrick Beatrix Krause‐Sorio Prabha Siddarth Katherine L. Narr Helen Lavretsky Default mode network connectivity and treatment response in geriatric depression Brain and Behavior default mode network depression memory randomized controlled trial |
| title | Default mode network connectivity and treatment response in geriatric depression |
| title_full | Default mode network connectivity and treatment response in geriatric depression |
| title_fullStr | Default mode network connectivity and treatment response in geriatric depression |
| title_full_unstemmed | Default mode network connectivity and treatment response in geriatric depression |
| title_short | Default mode network connectivity and treatment response in geriatric depression |
| title_sort | default mode network connectivity and treatment response in geriatric depression |
| topic | default mode network depression memory randomized controlled trial |
| url | https://doi.org/10.1002/brb3.2475 |
| work_keys_str_mv | AT lisaakilpatrick defaultmodenetworkconnectivityandtreatmentresponseingeriatricdepression AT beatrixkrausesorio defaultmodenetworkconnectivityandtreatmentresponseingeriatricdepression AT prabhasiddarth defaultmodenetworkconnectivityandtreatmentresponseingeriatricdepression AT katherinelnarr defaultmodenetworkconnectivityandtreatmentresponseingeriatricdepression AT helenlavretsky defaultmodenetworkconnectivityandtreatmentresponseingeriatricdepression |