Nanogap Electrode-Enabled Versatile Electrokinetic Manipulation of Nanometric Species in Fluids
Noninvasive manipulation of nanoscopic species in liquids has attracted considerable attention due to its potential applications in diverse fields. Many sophisticated methodologies have been developed to control and study nanoscopic entities, but the low-power, cost-effective, and versatile manipula...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/7/451 |
| _version_ | 1797433800114831360 |
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| author | Qiang Zhao Yunjiao Wang Bangyong Sun Deqiang Wang Gang Li |
| author_facet | Qiang Zhao Yunjiao Wang Bangyong Sun Deqiang Wang Gang Li |
| author_sort | Qiang Zhao |
| collection | DOAJ |
| description | Noninvasive manipulation of nanoscopic species in liquids has attracted considerable attention due to its potential applications in diverse fields. Many sophisticated methodologies have been developed to control and study nanoscopic entities, but the low-power, cost-effective, and versatile manipulation of nanometer-sized objects in liquids remains challenging. Here, we present a dielectrophoretic (DEP) manipulation technique based on nanogap electrodes, with which the on-demand capturing, enriching, and sorting of nano-objects in microfluidic systems can be achieved. The dielectrophoretic control unit consists of a pair of swelling-induced nanogap electrodes crossing a microchannel, generating a steep electric field gradient and thus strong DEP force for the effective manipulation of nano-objects microfluidics. The trapping, enriching, and sorting of nanoparticles and DNAs were performed with this device to demonstrate its potential applications in micro/nanofluidics, which opens an alternative avenue for the non-invasive manipulation and characterization of nanoparticles such as DNA, proteins, and viruses. |
| first_indexed | 2024-03-09T10:22:45Z |
| format | Article |
| id | doaj.art-f2e489ea7825485eb88ac3f419417ac2 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T10:22:45Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-f2e489ea7825485eb88ac3f419417ac22023-12-01T21:56:48ZengMDPI AGBiosensors2079-63742022-06-0112745110.3390/bios12070451Nanogap Electrode-Enabled Versatile Electrokinetic Manipulation of Nanometric Species in FluidsQiang Zhao0Yunjiao Wang1Bangyong Sun2Deqiang Wang3Gang Li4Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Defense Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Chongqing University, Chongqing 400044, ChinaChongqing Key Laboratory of Multi-Scale Manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chongqing 400714, ChinaKey Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Defense Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Chongqing University, Chongqing 400044, ChinaChongqing Key Laboratory of Multi-Scale Manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chongqing 400714, ChinaKey Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Defense Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Chongqing University, Chongqing 400044, ChinaNoninvasive manipulation of nanoscopic species in liquids has attracted considerable attention due to its potential applications in diverse fields. Many sophisticated methodologies have been developed to control and study nanoscopic entities, but the low-power, cost-effective, and versatile manipulation of nanometer-sized objects in liquids remains challenging. Here, we present a dielectrophoretic (DEP) manipulation technique based on nanogap electrodes, with which the on-demand capturing, enriching, and sorting of nano-objects in microfluidic systems can be achieved. The dielectrophoretic control unit consists of a pair of swelling-induced nanogap electrodes crossing a microchannel, generating a steep electric field gradient and thus strong DEP force for the effective manipulation of nano-objects microfluidics. The trapping, enriching, and sorting of nanoparticles and DNAs were performed with this device to demonstrate its potential applications in micro/nanofluidics, which opens an alternative avenue for the non-invasive manipulation and characterization of nanoparticles such as DNA, proteins, and viruses.https://www.mdpi.com/2079-6374/12/7/451nanogap electrodemicrofluidicsdielectrophoresisnanomanipulation |
| spellingShingle | Qiang Zhao Yunjiao Wang Bangyong Sun Deqiang Wang Gang Li Nanogap Electrode-Enabled Versatile Electrokinetic Manipulation of Nanometric Species in Fluids Biosensors nanogap electrode microfluidics dielectrophoresis nanomanipulation |
| title | Nanogap Electrode-Enabled Versatile Electrokinetic Manipulation of Nanometric Species in Fluids |
| title_full | Nanogap Electrode-Enabled Versatile Electrokinetic Manipulation of Nanometric Species in Fluids |
| title_fullStr | Nanogap Electrode-Enabled Versatile Electrokinetic Manipulation of Nanometric Species in Fluids |
| title_full_unstemmed | Nanogap Electrode-Enabled Versatile Electrokinetic Manipulation of Nanometric Species in Fluids |
| title_short | Nanogap Electrode-Enabled Versatile Electrokinetic Manipulation of Nanometric Species in Fluids |
| title_sort | nanogap electrode enabled versatile electrokinetic manipulation of nanometric species in fluids |
| topic | nanogap electrode microfluidics dielectrophoresis nanomanipulation |
| url | https://www.mdpi.com/2079-6374/12/7/451 |
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