Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults

Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults

Abstract Background Cytomegalovirus (CMV) infection leads to effector memory CD8+ T cell expansion and is associated with immune dysfunction in older adults. However, the molecular alterations of CMV-specific CD8+ T cells in CMV infected healthy young and middle-aged adults has not been fully charac...

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Bibliographic Details
Main Authors: Jian Lu, Guobing Chen, Arina Sorokina, Thomas Nguyen, Tonya Wallace, Cuong Nguyen, Christopher Dunn, Stephanie Wang, Samantha Ellis, Guixin Shi, Julia McKelvey, Alexei Sharov, Yu-Tsueng Liu, Jonathan Schneck, Nan-ping Weng
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Immunity & Ageing
Subjects:
Chronic infection
CD70
CMV-specific CD8+ T cells
Activation
Expansion
Online Access:https://doi.org/10.1186/s12979-022-00307-7

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