Suppression of AGR2 in a TGF-β-induced Smad regulatory pathway mediates epithelial-mesenchymal transition

Suppression of AGR2 in a TGF-β-induced Smad regulatory pathway mediates epithelial-mesenchymal transition

Abstract Background During cancer progression, epithelial cancer cells can be reprogrammed into mesenchymal-like cells with increased migratory potential through the process of epithelial-mesenchymal transition (EMT), representing an essential step of tumor progression towards metastatic state. AGR2...

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Bibliographic Details
Main Authors: Lucia Sommerova, Eva Ondrouskova, Borivoj Vojtesek, Roman Hrstka
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Cancer
Subjects:
AGR2
EMT
TGF-β
E-cadherin
Vimentin
Metastasis
Online Access:http://link.springer.com/article/10.1186/s12885-017-3537-5

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